FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980435011> ?p ?o ?g. }

• W2980435011 endingPage "A1987" @default.
• W2980435011 startingPage "A1987" @default.
• W2980435011 abstract "SESSION TITLE: Wednesday Medical Student/Resident Case Report Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: 10/23/2019 09:45 AM - 10:45 AM INTRODUCTION: Hypersensitivity pneumonitis (HP) is an immune-mediated pulmonary disease characterized by diffuse parenchymal inflammation following inhalation of an inciting antigen. Diagnosis requires clinical suspicion and a thorough exposure history. CASE PRESENTATION: A 39-year-old immunosuppresed woman was admitted with hypoxic respiratory failure. She reported several months of exertional dyspnea and general malaise, with acute worsening over the past couple days. Physical exam revealed a euvolemic woman with coarse breath sounds who was requiring 60L/min of high flow nasal cannula at an FiO2 of 1.0. Review of her records revealed two prior hospitalizations for similar but less severe symptoms. Her previous episodes responded to antibiotics but required her to go home on supplemental oxygen. Chest CT revealed diffuse bilateral consolidations, and a marked peripheral leukocytosis was present. Broad spectrum antibiotics were initiated. There was no clinical improvement at 24 hours. A lavage was lymphocytic. PCP was considered and TMP/SMX plus corticosteroids were added to her treatment plan. She promptly improved. A prior hypersensitivity panel that was positive for antibodies against Aspergillus species was discovered. Exposure history uncovered marijuana use that coincided with her current and prior respiratory symptoms. Hypersensitivity pneumonitis was diagnosed. She was discharged on a steroid taper and strict marijuana avoidance. At a six week follow up appointment she was off supplemental oxygen, symptom free, and with near complete resolution of imaging findings. DISCUSSION: Environmental fungi are well-established triggers for HP. The Aspergillus genus is a common contaminant of marijuana buds, along with species of Penicillium and Actinomycetes. They are able to pass through lit marijuana cigarettes and pipes, especially the spores of A. fumigatus. Knowing this, we felt confident making the diagnosis of HP in our patient. Her history of marijuana use coincided with her symptoms. She had anti-aspergillus IgG antibodies. Early images showed diffuse ground class opacities that progressed to consolidation with continued exposure, and her alveolar lavage displayed a lymphocytic component. Her symptoms resolved with corticosteroids and abstinence from marijuana. Literature implicating marijuana as a cause of HP exists, but is scant and consists mainly of case reports. With marijuana being one of the most popular illicit drugs of abuse, HP is either a very rare reaction or is underrecognized. Regardless, HP should be considered in any patient with the appropriate clinical picture and marijuana exposure, particularly those with antibodies reactive to common contaminants. CONCLUSIONS: Despite its social distinction as a generally benign substance, marijuana harbors many organic antigens and should be explored as a trigger for hypersensitivity pneumonitis and other exposure-related lung disease. Reference #1: Sforza GGR, Marinou A. Hypersensitivity pneumonitis: a complex lung disease. Clinical and Molecular Allergy. 2017;15. Reference #2: Kagen S, Kurup V, Sohnle P, Fink J. Marijuana smoking and fungal sensitization. Journal of Allergy and Clinical Immunology. 1983;71:389–93. DISCLOSURES: No relevant relationships by Daniel Hershberger, source=Web Response No relevant relationships by Daniel Van Kalsbeek, source=Web Response" @default.
• W2980435011 created "2019-10-25" @default.
• W2980435011 creator A5046767141 @default.
• W2980435011 creator A5069574380 @default.
• W2980435011 date "2019-10-01" @default.
• W2980435011 modified "2023-09-25" @default.
• W2980435011 title "HIGH-PERSENSITIVITY PNEUMONITIS" @default.
• W2980435011 doi "https://doi.org/10.1016/j.chest.2019.08.1965" @default.
• W2980435011 hasPublicationYear "2019" @default.
• W2980435011 type Work @default.
• W2980435011 sameAs 2980435011 @default.
• W2980435011 citedByCount "0" @default.
• W2980435011 crossrefType "journal-article" @default.
• W2980435011 hasAuthorship W2980435011A5046767141 @default.
• W2980435011 hasAuthorship W2980435011A5069574380 @default.
• W2980435011 hasBestOaLocation W29804350111 @default.
• W2980435011 hasConcept C118552586 @default.
• W2980435011 hasConcept C126322002 @default.
• W2980435011 hasConcept C141071460 @default.
• W2980435011 hasConcept C206179267 @default.
• W2980435011 hasConcept C2776888751 @default.
• W2980435011 hasConcept C2777134676 @default.
• W2980435011 hasConcept C2777714996 @default.
• W2980435011 hasConcept C2777914695 @default.
• W2980435011 hasConcept C2778074680 @default.
• W2980435011 hasConcept C2778923028 @default.
• W2980435011 hasConcept C2780334268 @default.
• W2980435011 hasConcept C2780505380 @default.
• W2980435011 hasConcept C2780724011 @default.
• W2980435011 hasConcept C71924100 @default.
• W2980435011 hasConceptScore W2980435011C118552586 @default.
• W2980435011 hasConceptScore W2980435011C126322002 @default.
• W2980435011 hasConceptScore W2980435011C141071460 @default.
• W2980435011 hasConceptScore W2980435011C206179267 @default.
• W2980435011 hasConceptScore W2980435011C2776888751 @default.
• W2980435011 hasConceptScore W2980435011C2777134676 @default.
• W2980435011 hasConceptScore W2980435011C2777714996 @default.
• W2980435011 hasConceptScore W2980435011C2777914695 @default.
• W2980435011 hasConceptScore W2980435011C2778074680 @default.
• W2980435011 hasConceptScore W2980435011C2778923028 @default.
• W2980435011 hasConceptScore W2980435011C2780334268 @default.
• W2980435011 hasConceptScore W2980435011C2780505380 @default.
• W2980435011 hasConceptScore W2980435011C2780724011 @default.
• W2980435011 hasConceptScore W2980435011C71924100 @default.
• W2980435011 hasIssue "4" @default.
• W2980435011 hasLocation W29804350111 @default.
• W2980435011 hasLocation W29804350112 @default.
• W2980435011 hasOpenAccess W2980435011 @default.
• W2980435011 hasPrimaryLocation W29804350111 @default.
• W2980435011 hasRelatedWork W1988109326 @default.
• W2980435011 hasRelatedWork W2047923528 @default.
• W2980435011 hasRelatedWork W2071981414 @default.
• W2980435011 hasRelatedWork W2155138342 @default.
• W2980435011 hasRelatedWork W2171277411 @default.
• W2980435011 hasRelatedWork W2348809255 @default.
• W2980435011 hasRelatedWork W2526316486 @default.
• W2980435011 hasRelatedWork W3197424647 @default.
• W2980435011 hasRelatedWork W4205308984 @default.
• W2980435011 hasRelatedWork W4312158471 @default.
• W2980435011 hasVolume "156" @default.
• W2980435011 isParatext "false" @default.
• W2980435011 isRetracted "false" @default.
• W2980435011 magId "2980435011" @default.
• W2980435011 workType "article" @default.