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- W2980446066 abstract "Tau and amyloid aggregates accumulation are the hallmarks of Alzheimer Disease neuropathology. While many studies have investigated their relationship to Grey Matter (GM), little is known about their effect on White Matter (WM). We used diffusion weighted imaging (DWI) in combination with PET imaging to investigate the relationship between Amyloid, Tau and the whole-brain regional WM fiber cross-sections. Preliminary data from 93 participants from the Triad cohort were analysed. All participants (Young = 6, CN= 30, CN (AB+) = 28, MCI (AB+) = 11 and AD = 18) underwent an Amyloid PET scan ([18F]AZD4694) a Tau PET scan ([18F]MK6240) and a multi-shell diffusion MRI. Global averaged SUVR values were calculated in individual native GM mask. DWI sequences were analysed using the Fixel-Based analysis from the MrTrix3 package (http://www.mrtrix.org/), enabling us to obtain a voxelwise measure of WM fibre cross-section (FC). Normal aging was associated with a strong reduction in WM FC in frontal and subcortical regions (Fig. 1a) while elderly control participants with and without amyloid pathology were not different (Fig. 1b). Compared to NC, MCI and AD patients showed a progressive decreased of WM FC in the uncinate fasciculus, hippocampal cingulum, inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF) and precuneus WM (Fig. 1c-d). A high Tau load in regions associated with Braak stage 1–2 (Fig. 1e) and Braak stage 3–4 (Fig. 1f) was associated with very similar patterns of WM FC reduction as those observed in MCI and AD. Tau and WM relationships persisted when adjusting for amyloid status." @default.
- W2980446066 created "2019-10-25" @default.
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- W2980446066 date "2019-07-01" @default.
- W2980446066 modified "2023-09-23" @default.
- W2980446066 title "O3-07-03: DECREASED WHITE MATTER FIBER CROSS-SECTION IS ASSOCIATED TO NORMAL AGING AND HIGHER TAU DEPOSITION INDEPENDENTLY OF AMYLOID" @default.
- W2980446066 doi "https://doi.org/10.1016/j.jalz.2019.06.4662" @default.
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