FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980451867> ?p ?o ?g. }

• W2980451867 endingPage "175" @default.
• W2980451867 startingPage "167" @default.
• W2980451867 abstract "Immune checkpoint inhibitors (ICPi) have shown major therapeutic successes when used in various cancers. In the HIV field a double benefit of such ICPi should result from their dual ability to restore in-vitro HIV-specific CD8 + T-cell functions and to enhance HIV production from reservoir cells, thus fulfilling the goals of the ‘shock and kill’ concept proposed as an HIV cure therapeutic strategy. We conducted a systematic review to identify studies reporting the tolerance profile of ICPi and their effects on HIV plasma loads (pVL), CD4 + cell count, HIV reservoirs (cell-associated HIV-DNA) and/or HIV-specific CD8 + T cells in PLWH. Thirty-one articles were included for a total 176 participants. Twelve percent of the participants experienced severe adverse events and 49% nonsevere adverse events. pVL remained stable in 91.9% participant, showed increases in 5.8% participant, and decreases in 2.3%. CD4 + cell count remained stable in 60.7% participants, showed increases in 24.6%, and decreases in 14.7%. Regarding ICPi effects on HIV-DNA and HIV-specific immunity, we identified three distinct profiles: profile I, transient pVL increases followed by a boost in HIV-specific CD8 + T cells concomitant to a decrease in HIV-DNA, reported in one participant. Profile II: increase in HIV-specific CD8 + T cells without changes in pVL or HIV-DNA, reported in three participants. III: no effect, reported in five participants. In conclusion, the clinical, virological and immunological safety profiles of ICPi reported in about 200 PLWH appear to be favorable but there are still modest results in terms of HIV cure strategy." @default.
• W2980451867 created "2019-10-25" @default.
• W2980451867 creator A5016185127 @default.
• W2980451867 creator A5017386021 @default.
• W2980451867 creator A5020254907 @default.
• W2980451867 creator A5042701070 @default.
• W2980451867 creator A5050061959 @default.
• W2980451867 creator A5072084563 @default.
• W2980451867 creator A5077812551 @default.
• W2980451867 creator A5078277664 @default.
• W2980451867 date "2020-02-01" @default.
• W2980451867 modified "2023-10-05" @default.
• W2980451867 title "Immune checkpoint inhibitors in people living with HIV: what about anti-HIV effects?" @default.
• W2980451867 cites W1857710824 @default.
• W2980451867 cites W1971112771 @default.
• W2980451867 cites W1978436252 @default.
• W2980451867 cites W1978674283 @default.
• W2980451867 cites W2028840312 @default.
• W2980451867 cites W2035852466 @default.
• W2980451867 cites W2074061250 @default.
• W2980451867 cites W2085384576 @default.
• W2980451867 cites W2088541970 @default.
• W2980451867 cites W2098194107 @default.
• W2980451867 cites W2102336941 @default.
• W2980451867 cites W2118015571 @default.
• W2980451867 cites W2123063882 @default.
• W2980451867 cites W2124114936 @default.
• W2980451867 cites W2128965385 @default.
• W2980451867 cites W2140875987 @default.
• W2980451867 cites W2142014345 @default.
• W2980451867 cites W2146666488 @default.
• W2980451867 cites W2151980311 @default.
• W2980451867 cites W2158867438 @default.
• W2980451867 cites W2166662937 @default.
• W2980451867 cites W2222086386 @default.
• W2980451867 cites W2263584512 @default.
• W2980451867 cites W2331886819 @default.
• W2980451867 cites W2344722403 @default.
• W2980451867 cites W2410813747 @default.
• W2980451867 cites W2414537326 @default.
• W2980451867 cites W2462078368 @default.
• W2980451867 cites W2466398959 @default.
• W2980451867 cites W2513534886 @default.
• W2980451867 cites W2556485149 @default.
• W2980451867 cites W2565170802 @default.
• W2980451867 cites W2602761986 @default.
• W2980451867 cites W2605530771 @default.
• W2980451867 cites W2609973112 @default.
• W2980451867 cites W2617719966 @default.
• W2980451867 cites W2626017415 @default.
• W2980451867 cites W2726019666 @default.
• W2980451867 cites W2731052242 @default.
• W2980451867 cites W2754796303 @default.
• W2980451867 cites W2755874731 @default.
• W2980451867 cites W2763265527 @default.
• W2980451867 cites W2765356378 @default.
• W2980451867 cites W2773063307 @default.
• W2980451867 cites W2774734531 @default.
• W2980451867 cites W2782233255 @default.
• W2980451867 cites W2783194048 @default.
• W2980451867 cites W2794128101 @default.
• W2980451867 cites W2795698310 @default.
• W2980451867 cites W2796582438 @default.
• W2980451867 cites W2801428242 @default.
• W2980451867 cites W2802312153 @default.
• W2980451867 cites W2806703026 @default.
• W2980451867 cites W2866189919 @default.
• W2980451867 cites W2883627741 @default.
• W2980451867 cites W2884573845 @default.
• W2980451867 cites W2884859985 @default.
• W2980451867 cites W2890934903 @default.
• W2980451867 cites W2895171336 @default.
• W2980451867 cites W2897435840 @default.
• W2980451867 cites W2899592034 @default.
• W2980451867 cites W2900307840 @default.
• W2980451867 cites W2911264428 @default.
• W2980451867 cites W2913946693 @default.
• W2980451867 cites W2946998144 @default.
• W2980451867 cites W2955805012 @default.
• W2980451867 doi "https://doi.org/10.1097/qad.0000000000002397" @default.
• W2980451867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31634190" @default.
• W2980451867 hasPublicationYear "2020" @default.
• W2980451867 type Work @default.
• W2980451867 sameAs 2980451867 @default.
• W2980451867 citedByCount "22" @default.
• W2980451867 countsByYear W29804518672020 @default.
• W2980451867 countsByYear W29804518672021 @default.
• W2980451867 countsByYear W29804518672022 @default.
• W2980451867 countsByYear W29804518672023 @default.
• W2980451867 crossrefType "journal-article" @default.
• W2980451867 hasAuthorship W2980451867A5016185127 @default.
• W2980451867 hasAuthorship W2980451867A5017386021 @default.
• W2980451867 hasAuthorship W2980451867A5020254907 @default.
• W2980451867 hasAuthorship W2980451867A5042701070 @default.
• W2980451867 hasAuthorship W2980451867A5050061959 @default.
• W2980451867 hasAuthorship W2980451867A5072084563 @default.
• W2980451867 hasAuthorship W2980451867A5077812551 @default.
• W2980451867 hasAuthorship W2980451867A5078277664 @default.

• next