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- W2980452468 abstract "Abstract Wolbachia are Gram‐negative endosymbionts that are known to cause embryonic lethality when infected male insects mate with uninfected females or with females carrying a different strain of Wolbachia , a situation characterized as cytoplasmic incompatibility (CI). However, the mechanism of CI is not yet fully understood, although recent studies on Drosophila melanogaster have achieved great progress. Here, we found that Wolbachia infection caused changes in the expressions of several immunity‐related genes, including significant upregulation of kenny ( key ), in the testes of D. melanogaster . Overexpression of key in fly testes led to a significant decrease in egg hatch rates when these flies mate with wild‐type females. Wolbachia ‐infected females could rescue this embryonic lethality. Furthermore, in key overexpressing testes terminal deoxynucleotidyl transferase‐mediated dUTP‐biotin nick‐end labeling signal was significantly stronger than in the control testes, and the level of reactive oxygen species was significantly increased. Overexpression of key also resulted in alterations of some other immunity‐related gene expressions, including the downregulation of Zn72D . Knockdown of Zn72D in fly testes also led to a significant decrease in egg hatch rates. These results suggest that Wolbachia might induce the defect in male host fertility by immunity‐related pathways and thus cause an oxidative damage and cell death in male testes." @default.
- W2980452468 created "2019-10-25" @default.
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- W2980452468 date "2019-11-12" @default.
- W2980452468 modified "2023-10-16" @default.
- W2980452468 title "<i>Wolbachia</i> ‐induced expression of <i>kenny</i> gene in testes affects male fertility in <i>Drosophila melanogaster</i>" @default.
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- W2980452468 doi "https://doi.org/10.1111/1744-7917.12730" @default.
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