Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980454433> ?p ?o ?g. }
- W2980454433 endingPage "501" @default.
- W2980454433 startingPage "491" @default.
- W2980454433 abstract "Abstract In recent years, numerous overgrowth syndromes have been found to be caused by pathogenic DNA sequence variants in “epigenes,” genes that encode proteins that function in epigenetic regulation. Epigenetic marks, including DNA methylation (DNAm), histone modifications and chromatin conformation, have emerged as a vital genome‐wide regulatory mechanism that modulate the transcriptome temporally and spatially to drive normal developmental and cellular processes. Evidence suggests that epigenetic marks are layered and engage in crosstalk, in that disruptions of any one component of the epigenetic machinery impact the others. This interdependence of epigenetic marks underpins the recent identification of gene‐specific DNAm signatures for a variety of disorders caused by pathogenic variants in epigenes. Here, we discuss the power of DNAm signatures with respect to furthering our understanding of disease pathophysiology, enhancing the efficacy of molecular diagnostics and identifying new targets for therapeutics of overgrowth syndromes. These findings highlight the promise of the field of epigenomics to provide unprecedented insights into disease mechanisms generating a host of opportunities to advance precision medicine." @default.
- W2980454433 created "2019-10-25" @default.
- W2980454433 creator A5002180539 @default.
- W2980454433 creator A5017430701 @default.
- W2980454433 creator A5036444068 @default.
- W2980454433 date "2019-10-16" @default.
- W2980454433 modified "2023-09-28" @default.
- W2980454433 title "Epigenetic signatures in overgrowth syndromes: Translational opportunities" @default.
- W2980454433 cites W1504730632 @default.
- W2980454433 cites W1528589025 @default.
- W2980454433 cites W1917476040 @default.
- W2980454433 cites W1939472951 @default.
- W2980454433 cites W1967841068 @default.
- W2980454433 cites W1975528145 @default.
- W2980454433 cites W1976626368 @default.
- W2980454433 cites W1979594866 @default.
- W2980454433 cites W1979856142 @default.
- W2980454433 cites W1981354816 @default.
- W2980454433 cites W1981615602 @default.
- W2980454433 cites W1983628159 @default.
- W2980454433 cites W1990284480 @default.
- W2980454433 cites W1991667131 @default.
- W2980454433 cites W1994235327 @default.
- W2980454433 cites W1999775510 @default.
- W2980454433 cites W2008809596 @default.
- W2980454433 cites W2011104528 @default.
- W2980454433 cites W2043267753 @default.
- W2980454433 cites W2046459630 @default.
- W2980454433 cites W2048222359 @default.
- W2980454433 cites W2048424315 @default.
- W2980454433 cites W2051978340 @default.
- W2980454433 cites W2062315689 @default.
- W2980454433 cites W2063714349 @default.
- W2980454433 cites W2075956161 @default.
- W2980454433 cites W2081098333 @default.
- W2980454433 cites W2089343670 @default.
- W2980454433 cites W2091605994 @default.
- W2980454433 cites W2106482095 @default.
- W2980454433 cites W2117456217 @default.
- W2980454433 cites W2117793442 @default.
- W2980454433 cites W2117902955 @default.
- W2980454433 cites W2118939524 @default.
- W2980454433 cites W2124207075 @default.
- W2980454433 cites W2127884678 @default.
- W2980454433 cites W2128300020 @default.
- W2980454433 cites W2129867386 @default.
- W2980454433 cites W2130141192 @default.
- W2980454433 cites W2133404976 @default.
- W2980454433 cites W2142336039 @default.
- W2980454433 cites W2148264682 @default.
- W2980454433 cites W2154719999 @default.
- W2980454433 cites W2156488881 @default.
- W2980454433 cites W2156880972 @default.
- W2980454433 cites W2158217645 @default.
- W2980454433 cites W2162998664 @default.
- W2980454433 cites W2163818283 @default.
- W2980454433 cites W2165673819 @default.
- W2980454433 cites W2213332789 @default.
- W2980454433 cites W2266116507 @default.
- W2980454433 cites W2267376195 @default.
- W2980454433 cites W2312839459 @default.
- W2980454433 cites W2398601327 @default.
- W2980454433 cites W2424103524 @default.
- W2980454433 cites W2468398806 @default.
- W2980454433 cites W2507113299 @default.
- W2980454433 cites W2515141406 @default.
- W2980454433 cites W2529670608 @default.
- W2980454433 cites W2550031332 @default.
- W2980454433 cites W2560391173 @default.
- W2980454433 cites W2589005789 @default.
- W2980454433 cites W2590723071 @default.
- W2980454433 cites W2594540404 @default.
- W2980454433 cites W2610666651 @default.
- W2980454433 cites W2611444105 @default.
- W2980454433 cites W2785962058 @default.
- W2980454433 cites W2883557078 @default.
- W2980454433 cites W2900595482 @default.
- W2980454433 cites W2912555542 @default.
- W2980454433 cites W2936777733 @default.
- W2980454433 cites W2952885806 @default.
- W2980454433 cites W2957019321 @default.
- W2980454433 cites W4231379543 @default.
- W2980454433 doi "https://doi.org/10.1002/ajmg.c.31745" @default.
- W2980454433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31828978" @default.
- W2980454433 hasPublicationYear "2019" @default.
- W2980454433 type Work @default.
- W2980454433 sameAs 2980454433 @default.
- W2980454433 citedByCount "9" @default.
- W2980454433 countsByYear W29804544332019 @default.
- W2980454433 countsByYear W29804544332020 @default.
- W2980454433 countsByYear W29804544332021 @default.
- W2980454433 countsByYear W29804544332022 @default.
- W2980454433 countsByYear W29804544332023 @default.
- W2980454433 crossrefType "journal-article" @default.
- W2980454433 hasAuthorship W2980454433A5002180539 @default.
- W2980454433 hasAuthorship W2980454433A5017430701 @default.
- W2980454433 hasAuthorship W2980454433A5036444068 @default.
- W2980454433 hasConcept C104317684 @default.