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• W2980454739 abstract "Abstract Recent genome-wide association studies have identified numerous loci associated with neuropsychiatric disorders. The majority of these are in non-coding regions, and are commonly assigned to the nearest gene along the genome. However, this approach neglects the three-dimensional organisation of the genome, and the fact that the genome contains arrays of extremely conserved non-coding elements termed genomic regulatory blocks (GRBs), which can be utilized to detect genes under long-range developmental regulation. Here we review a GRB-based approach to assign loci in non-coding regions to potential target genes, and apply it to reanalyse the results of one of the largest schizophrenia GWAS (SWG PGC, 2014). We further apply this approach to GWAS data from two related neuropsychiatric disorders—autism spectrum disorder and bipolar disorder—to show that it is applicable to developmental disorders in general. We find that disease-associated SNPs are overrepresented in GRBs and that the GRB model is a powerful tool for linking these SNPs to their correct target genes under long-range regulation. Our analysis identifies novel genes not previously implicated in schizophrenia and corroborates a number of predicted targets from the original study. The results are available as an online resource in which the genomic context and the strength of enhancer–promoter associations can be browsed for each schizophrenia-associated SNP." @default.
• W2980454739 created "2019-10-25" @default.
• W2980454739 creator A5000181149 @default.
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• W2980454739 creator A5076672215 @default.
• W2980454739 date "2019-10-15" @default.
• W2980454739 modified "2023-10-17" @default.
• W2980454739 title "Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks" @default.
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• W2980454739 cites W1901277266 @default.
• W2980454739 cites W1963673462 @default.
• W2980454739 cites W1971299565 @default.
• W2980454739 cites W1980991473 @default.
• W2980454739 cites W1983719168 @default.
• W2980454739 cites W1984615306 @default.
• W2980454739 cites W1987942611 @default.
• W2980454739 cites W2004469093 @default.
• W2980454739 cites W2015845481 @default.
• W2980454739 cites W2018332195 @default.
• W2980454739 cites W2019465651 @default.
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• W2980454739 cites W2025306791 @default.
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• W2980454739 cites W2070021921 @default.
• W2980454739 cites W2078059415 @default.
• W2980454739 cites W2078650973 @default.
• W2980454739 cites W2080563390 @default.
• W2980454739 cites W2081036744 @default.
• W2980454739 cites W2090212249 @default.
• W2980454739 cites W2093211742 @default.
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• W2980454739 cites W2096987707 @default.
• W2980454739 cites W2098318348 @default.
• W2980454739 cites W2100990361 @default.
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• W2980454739 cites W2116251070 @default.
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• W2980454739 cites W2118910836 @default.
• W2980454739 cites W2119598138 @default.
• W2980454739 cites W2127634492 @default.
• W2980454739 cites W2127724005 @default.
• W2980454739 cites W2127922938 @default.
• W2980454739 cites W2139852368 @default.
• W2980454739 cites W2145144631 @default.
• W2980454739 cites W2146809691 @default.
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• W2980454739 cites W2486995625 @default.
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• W2980454739 cites W2534005127 @default.
• W2980454739 cites W2553838260 @default.
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• W2980454739 cites W2763058017 @default.
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• W2980454739 doi "https://doi.org/10.1038/s41380-019-0518-x" @default.
• W2980454739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6906185" @default.
• W2980454739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31616042" @default.
• W2980454739 hasPublicationYear "2019" @default.
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