Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980454872> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W2980454872 abstract "The blood-cerebrospinal fluid barrier (CSF) forms a unique interface between blood and brain. It consists of a single cell layer, called choroid plexus epithelium, situated at the interface of blood and CSF. The choroid plexus epithelium has different important functions: it forms a barrier to protect the brain from fluctuations in the blood thereby assuring brain homeostasis, produces CSF and is responsible for the active removal of toxic molecules from the brain. In recent years, the choroid plexus epithelium has gained increasing attention, especially its role in different pathologies. Our mouse studies show that systemic inflammation induces increased blood-CSF barrier leakage and peripheral inflammatory triggers also induce an increase in extracellular vesicle release by the choroid plexus epithelium into the CSF. Strikingly, these choroid plexus-derived EVs are able to enter the brain parenchyma, are taken up by astrocytes and microglia and transfer a pro-inflammatory message to the brain. Moreover, systemic inflammation sensitizes to the development of amyloid beta pathology. In conclusion, we found that peripheral inflammatory triggers affect barrier and secretory activity of the choroid plexus epithelium and influence disease pathology in Alzheimer's disease." @default.
- W2980454872 created "2019-10-25" @default.
- W2980454872 creator A5043807997 @default.
- W2980454872 date "2019-07-01" @default.
- W2980454872 modified "2023-09-27" @default.
- W2980454872 title "S5‐01‐04: SYSTEMIC INFLAMMATION SIGNALING TO THE BRAIN" @default.
- W2980454872 doi "https://doi.org/10.1016/j.jalz.2019.06.4822" @default.
- W2980454872 hasPublicationYear "2019" @default.
- W2980454872 type Work @default.
- W2980454872 sameAs 2980454872 @default.
- W2980454872 citedByCount "0" @default.
- W2980454872 crossrefType "journal-article" @default.
- W2980454872 hasAuthorship W2980454872A5043807997 @default.
- W2980454872 hasConcept C134018914 @default.
- W2980454872 hasConcept C142724271 @default.
- W2980454872 hasConcept C177779419 @default.
- W2980454872 hasConcept C196822366 @default.
- W2980454872 hasConcept C203014093 @default.
- W2980454872 hasConcept C2776252253 @default.
- W2980454872 hasConcept C2776538271 @default.
- W2980454872 hasConcept C2776914184 @default.
- W2980454872 hasConcept C2778402981 @default.
- W2980454872 hasConcept C2779651940 @default.
- W2980454872 hasConcept C2779830541 @default.
- W2980454872 hasConcept C529278444 @default.
- W2980454872 hasConcept C529295009 @default.
- W2980454872 hasConcept C63645605 @default.
- W2980454872 hasConcept C71924100 @default.
- W2980454872 hasConcept C86803240 @default.
- W2980454872 hasConcept C95444343 @default.
- W2980454872 hasConceptScore W2980454872C134018914 @default.
- W2980454872 hasConceptScore W2980454872C142724271 @default.
- W2980454872 hasConceptScore W2980454872C177779419 @default.
- W2980454872 hasConceptScore W2980454872C196822366 @default.
- W2980454872 hasConceptScore W2980454872C203014093 @default.
- W2980454872 hasConceptScore W2980454872C2776252253 @default.
- W2980454872 hasConceptScore W2980454872C2776538271 @default.
- W2980454872 hasConceptScore W2980454872C2776914184 @default.
- W2980454872 hasConceptScore W2980454872C2778402981 @default.
- W2980454872 hasConceptScore W2980454872C2779651940 @default.
- W2980454872 hasConceptScore W2980454872C2779830541 @default.
- W2980454872 hasConceptScore W2980454872C529278444 @default.
- W2980454872 hasConceptScore W2980454872C529295009 @default.
- W2980454872 hasConceptScore W2980454872C63645605 @default.
- W2980454872 hasConceptScore W2980454872C71924100 @default.
- W2980454872 hasConceptScore W2980454872C86803240 @default.
- W2980454872 hasConceptScore W2980454872C95444343 @default.
- W2980454872 hasIssue "7S_Part_31" @default.
- W2980454872 hasLocation W29804548721 @default.
- W2980454872 hasOpenAccess W2980454872 @default.
- W2980454872 hasPrimaryLocation W29804548721 @default.
- W2980454872 hasRelatedWork W1518894611 @default.
- W2980454872 hasRelatedWork W1573527476 @default.
- W2980454872 hasRelatedWork W182956977 @default.
- W2980454872 hasRelatedWork W2102119830 @default.
- W2980454872 hasRelatedWork W2163762710 @default.
- W2980454872 hasRelatedWork W2275681820 @default.
- W2980454872 hasRelatedWork W2547638099 @default.
- W2980454872 hasRelatedWork W3165448279 @default.
- W2980454872 hasRelatedWork W4310962140 @default.
- W2980454872 hasRelatedWork W602816933 @default.
- W2980454872 hasVolume "15" @default.
- W2980454872 isParatext "false" @default.
- W2980454872 isRetracted "false" @default.
- W2980454872 magId "2980454872" @default.
- W2980454872 workType "article" @default.