FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980454977> ?p ?o ?g. }

• W2980454977 endingPage "5591" @default.
• W2980454977 startingPage "5576" @default.
• W2980454977 abstract "// Balaji Krishnamachary 1 , Dharmalingam Subramaniam 1 , Prasad Dandawate 1 , Sivapriya Ponnurangam 1 , Pugazhendhi Srinivasan 1 , Prabhu Ramamoorthy 1 , Shahid Umar 2 , Sufi Mary Thomas 3 , Animesh Dhar 1 , Seth Septer 4 , Scott J. Weir 1 , Thomas Attard 5 and Shrikant Anant 1 1 Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS, USA 2 Department of General Surgery, University of Kansas Medical Center, Kansas City, KS, USA 3 Department of Otolaryngology, University of Kansas Medical Center, Kansas City, KS, USA 4 Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Colorado, Aurora, CO, USA 5 Department of Pediatrics, Division of Gastroenterology, Children&#x2019;s Mercy Hospital, Kansas City, KS, USA Correspondence to: Shrikant Anant, email: sanant@kumc.edu Keywords: Wnt signaling; beta-catenin; natural product; tumor xenograft; preventive agent Received: April 10, 2019     Accepted: July 17, 2019     Published: September 24, 2019 ABSTRACT Given that colon cancer is the third most common cancer in incidence and cause of death in the United States, and current treatment modalities are insufficient, there is a need to develop novel agents. Towards this, here we focus on &#x03B3;-Mangostin, a bioactive compound present in the Mangosteen ( Garcinia mangostana ) fruit. &#x03B3;-Mangostin suppressed proliferation and colony formation, and induced cell cycle arrest and apoptosis of colon cancer cell lines. Further, &#x03B3;-Mangostin inhibited colonosphere formation. Molecular docking and CETSA (Cellular thermal shift assay) binding assays demonstrated that &#x03B3;-Mangostin interacts with transcription factor TCF4 (T-Cell Factor 4) at the &#x03B2;-catenin binding domain with the binding energy of -5.5 Kcal/mol. Moreover, &#x03B3;-Mangostin treatment decreased TCF4 expression and reduced TCF reporter activity. The compound also suppressed the expression of Wnt signaling target proteins cyclin D1 and c-Myc, and stem cell markers such as LGR5, DCLK1 and CD44. To determine the effect of &#x03B3;-Mangostin on tumor growth in vivo , we administered nude mice harboring HCT116 tumor xenografts with 5 mg/Kg of &#x03B3;-Mangostin intraperitoneally for 21 days. &#x03B3;-Mangostin treatment significantly suppressed tumor growth, with notably lowered tumor volume and weight. In addition, western blot analysis revealed a significant decrease in the expression of TCF4 and its downstream targets such as cyclin D1 and c-Myc. Together, these data suggest that &#x03B3;-Mangostin inhibits colon cancer growth through targeting TCF4. &#x03B3;-Mangostin may be a potential therapeutic agent for colon cancer." @default.
• W2980454977 created "2019-10-25" @default.
• W2980454977 creator A5002299630 @default.
• W2980454977 creator A5016868651 @default.
• W2980454977 creator A5029226618 @default.
• W2980454977 creator A5035668092 @default.
• W2980454977 creator A5041349401 @default.
• W2980454977 creator A5066378974 @default.
• W2980454977 creator A5072004481 @default.
• W2980454977 creator A5073317376 @default.
• W2980454977 creator A5079465137 @default.
• W2980454977 creator A5079468111 @default.
• W2980454977 creator A5083384571 @default.
• W2980454977 creator A5085590864 @default.
• W2980454977 creator A5089269227 @default.
• W2980454977 date "2019-09-24" @default.
• W2980454977 modified "2023-10-16" @default.
• W2980454977 title "Targeting transcription factor TCF4 by γ-Mangostin, a natural xanthone" @default.
• W2980454977 cites W1588334150 @default.
• W2980454977 cites W1591802054 @default.
• W2980454977 cites W1838098262 @default.
• W2980454977 cites W1904120886 @default.
• W2980454977 cites W1968570471 @default.
• W2980454977 cites W1969717239 @default.
• W2980454977 cites W1977169442 @default.
• W2980454977 cites W1983214648 @default.
• W2980454977 cites W1983549526 @default.
• W2980454977 cites W1993251792 @default.
• W2980454977 cites W1994039628 @default.
• W2980454977 cites W1999608828 @default.
• W2980454977 cites W2001338466 @default.
• W2980454977 cites W2002404925 @default.
• W2980454977 cites W2002423563 @default.
• W2980454977 cites W2006419043 @default.
• W2980454977 cites W2007981754 @default.
• W2980454977 cites W2008757158 @default.
• W2980454977 cites W2016763331 @default.
• W2980454977 cites W2016808773 @default.
• W2980454977 cites W2021832401 @default.
• W2980454977 cites W2027150010 @default.
• W2980454977 cites W2042173734 @default.
• W2980454977 cites W2049346003 @default.
• W2980454977 cites W2057166192 @default.
• W2980454977 cites W2057439779 @default.
• W2980454977 cites W2061822687 @default.
• W2980454977 cites W2064027874 @default.
• W2980454977 cites W2073537907 @default.
• W2980454977 cites W2080363237 @default.
• W2980454977 cites W2091996588 @default.
• W2980454977 cites W2095457605 @default.
• W2980454977 cites W2096934743 @default.
• W2980454977 cites W2109069210 @default.
• W2980454977 cites W2109453910 @default.
• W2980454977 cites W2109871727 @default.
• W2980454977 cites W2124099438 @default.
• W2980454977 cites W2139415460 @default.
• W2980454977 cites W2146645376 @default.
• W2980454977 cites W2148922014 @default.
• W2980454977 cites W2153899496 @default.
• W2980454977 cites W2154312575 @default.
• W2980454977 cites W2162020555 @default.
• W2980454977 cites W2164946454 @default.
• W2980454977 cites W2165831605 @default.
• W2980454977 cites W2205557173 @default.
• W2980454977 cites W2261100060 @default.
• W2980454977 cites W2314613119 @default.
• W2980454977 cites W2339187372 @default.
• W2980454977 cites W2340277234 @default.
• W2980454977 cites W2470575266 @default.
• W2980454977 cites W2594414604 @default.
• W2980454977 cites W2610688323 @default.
• W2980454977 cites W2756675167 @default.
• W2980454977 cites W2771031544 @default.
• W2980454977 cites W2801493934 @default.
• W2980454977 cites W2901260514 @default.
• W2980454977 cites W2903870145 @default.
• W2980454977 cites W2911188335 @default.
• W2980454977 doi "https://doi.org/10.18632/oncotarget.27159" @default.
• W2980454977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6771460" @default.
• W2980454977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31608135" @default.
• W2980454977 hasPublicationYear "2019" @default.
• W2980454977 type Work @default.
• W2980454977 sameAs 2980454977 @default.
• W2980454977 citedByCount "13" @default.
• W2980454977 countsByYear W29804549772020 @default.
• W2980454977 countsByYear W29804549772021 @default.
• W2980454977 countsByYear W29804549772022 @default.
• W2980454977 countsByYear W29804549772023 @default.
• W2980454977 crossrefType "journal-article" @default.
• W2980454977 hasAuthorship W2980454977A5002299630 @default.
• W2980454977 hasAuthorship W2980454977A5016868651 @default.
• W2980454977 hasAuthorship W2980454977A5029226618 @default.
• W2980454977 hasAuthorship W2980454977A5035668092 @default.
• W2980454977 hasAuthorship W2980454977A5041349401 @default.
• W2980454977 hasAuthorship W2980454977A5066378974 @default.
• W2980454977 hasAuthorship W2980454977A5072004481 @default.
• W2980454977 hasAuthorship W2980454977A5073317376 @default.
• W2980454977 hasAuthorship W2980454977A5079465137 @default.

• next