FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980455009> ?p ?o ?g. }

• W2980455009 endingPage "117" @default.
• W2980455009 startingPage "117" @default.
• W2980455009 abstract "Objective: SYM 2081 ((2S,4R)-4-methylglutamic acid), an agonist and functional antagonist of the kainite receptor, has shown a neuroprotective effect in neurodegenerative diseases in adults but little is known concerning perinatal hypoxic-ischemic encephalopathy. This study is designed to evaluate whether SYM 2081 has preventive mechanisms via anti-apoptosis to gain further insight into neuroprotective roles of SYM 2081.Methods: In an in vivo animal model, the left carotid artery was ligated in 7-day-old Sprague-Dawley rat pups. The pups were divided into six groups: normoxia (N), hypoxia (8% O2, 92% N2) (H), H with shamoperation, H with operation (HO), HO treated with vehicle and HO treated with SYM 2081. In an in vitro model, the cultured embryonic cortical neuronal cells were divided into three groups: normoxia (95% air, 5% CO2), hypoxia (94% N2, 5% CO2) (Hc), and Hc treated with SYM 2081 before a hypoxic insult. Apoptosis was assessed using western blots and real-time polymerase chain reaction with Bcl-2, Bax, and caspase-3 antibodies and mRNAs.Results: In both in vitro and in vivo studies, Bcl-2 expression increased, whereas expressions of Bax, caspase-3, and the ratio of Bax/Bcl-2 were reduced with SYM 2081 treatment resulting in improved cell survival.Conclusion: This study showed that SYM 2081 exerts a neuroprotective effect against hypoxic-ischemic injury through modulating apoptotic signaling pathways." @default.
• W2980455009 created "2019-10-25" @default.
• W2980455009 creator A5008230955 @default.
• W2980455009 creator A5028185603 @default.
• W2980455009 creator A5051569706 @default.
• W2980455009 creator A5054955615 @default.
• W2980455009 creator A5056321941 @default.
• W2980455009 creator A5068128114 @default.
• W2980455009 creator A5089127829 @default.
• W2980455009 date "2019-01-01" @default.
• W2980455009 modified "2023-09-27" @default.
• W2980455009 title "SYM 2081 Exerts Neuroprotective Effect Modulating Anti-Apoptosis in the Hypoxic-Ischemic Brain Injury of Neonatal Rats" @default.
• W2980455009 cites W1426653110 @default.
• W2980455009 cites W1449002812 @default.
• W2980455009 cites W1502853049 @default.
• W2980455009 cites W1653076540 @default.
• W2980455009 cites W1946055346 @default.
• W2980455009 cites W1977258127 @default.
• W2980455009 cites W1991453028 @default.
• W2980455009 cites W1993614010 @default.
• W2980455009 cites W1995363050 @default.
• W2980455009 cites W2000773418 @default.
• W2980455009 cites W2004568898 @default.
• W2980455009 cites W2007377472 @default.
• W2980455009 cites W2015424325 @default.
• W2980455009 cites W2020577322 @default.
• W2980455009 cites W2021275515 @default.
• W2980455009 cites W2024718726 @default.
• W2980455009 cites W2026899473 @default.
• W2980455009 cites W2039866583 @default.
• W2980455009 cites W2039992040 @default.
• W2980455009 cites W2045875853 @default.
• W2980455009 cites W2062384458 @default.
• W2980455009 cites W2067190171 @default.
• W2980455009 cites W2072310161 @default.
• W2980455009 cites W2073326800 @default.
• W2980455009 cites W2078810845 @default.
• W2980455009 cites W2080160572 @default.
• W2980455009 cites W2080848309 @default.
• W2980455009 cites W2088976874 @default.
• W2980455009 cites W2094978516 @default.
• W2980455009 cites W2107277218 @default.
• W2980455009 cites W2109912660 @default.
• W2980455009 cites W2128024050 @default.
• W2980455009 cites W2134803312 @default.
• W2980455009 cites W2136967026 @default.
• W2980455009 cites W2152660399 @default.
• W2980455009 cites W2265376283 @default.
• W2980455009 cites W2269031225 @default.
• W2980455009 cites W2325008670 @default.
• W2980455009 cites W2441939915 @default.
• W2980455009 cites W2546929174 @default.
• W2980455009 doi "https://doi.org/10.14734/pn.2019.30.3.117" @default.
• W2980455009 hasPublicationYear "2019" @default.
• W2980455009 type Work @default.
• W2980455009 sameAs 2980455009 @default.
• W2980455009 citedByCount "0" @default.
• W2980455009 crossrefType "journal-article" @default.
• W2980455009 hasAuthorship W2980455009A5008230955 @default.
• W2980455009 hasAuthorship W2980455009A5028185603 @default.
• W2980455009 hasAuthorship W2980455009A5051569706 @default.
• W2980455009 hasAuthorship W2980455009A5054955615 @default.
• W2980455009 hasAuthorship W2980455009A5056321941 @default.
• W2980455009 hasAuthorship W2980455009A5068128114 @default.
• W2980455009 hasAuthorship W2980455009A5089127829 @default.
• W2980455009 hasBestOaLocation W29804550091 @default.
• W2980455009 hasConcept C169760540 @default.
• W2980455009 hasConcept C185592680 @default.
• W2980455009 hasConcept C190283241 @default.
• W2980455009 hasConcept C25498285 @default.
• W2980455009 hasConcept C42219234 @default.
• W2980455009 hasConcept C55493867 @default.
• W2980455009 hasConcept C71924100 @default.
• W2980455009 hasConcept C86803240 @default.
• W2980455009 hasConcept C98274493 @default.
• W2980455009 hasConceptScore W2980455009C169760540 @default.
• W2980455009 hasConceptScore W2980455009C185592680 @default.
• W2980455009 hasConceptScore W2980455009C190283241 @default.
• W2980455009 hasConceptScore W2980455009C25498285 @default.
• W2980455009 hasConceptScore W2980455009C42219234 @default.
• W2980455009 hasConceptScore W2980455009C55493867 @default.
• W2980455009 hasConceptScore W2980455009C71924100 @default.
• W2980455009 hasConceptScore W2980455009C86803240 @default.
• W2980455009 hasConceptScore W2980455009C98274493 @default.
• W2980455009 hasFunder F4320321189 @default.
• W2980455009 hasIssue "3" @default.
• W2980455009 hasLocation W29804550091 @default.
• W2980455009 hasOpenAccess W2980455009 @default.
• W2980455009 hasPrimaryLocation W29804550091 @default.
• W2980455009 hasRelatedWork W2050697792 @default.
• W2980455009 hasRelatedWork W2067467642 @default.
• W2980455009 hasRelatedWork W2077302930 @default.
• W2980455009 hasRelatedWork W2084272464 @default.
• W2980455009 hasRelatedWork W2170431845 @default.
• W2980455009 hasRelatedWork W2747715884 @default.
• W2980455009 hasRelatedWork W2748952813 @default.
• W2980455009 hasRelatedWork W2899084033 @default.
• W2980455009 hasRelatedWork W2965035470 @default.

• next