Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980456224> ?p ?o ?g. }
- W2980456224 abstract "Abstract Environment shapes development through a phenomenon called developmental plasticity. Deciphering its genetic basis has implications for understanding evolution and adaptation to novel environments, yet molecular studies are scarce. Here, we expanded the gene regulatory network controlling predatory vs. non-predatory morphology in the nematode Pristionchus pacificus . First, we isolated a mutant in the nuclear hormone receptor nhr-1 with a previously unseen phenotypic effect. It disrupts mouth-form determination and results in animals combining features of both wild-type morphs. Further, we identified common targets of NHR-1 and the previously identified nuclear hormone receptor NHR-40 through transcriptomics. Unlike their highly conserved regulators, the target genes have no orthologs in Caenorhabditis elegans and likely result from lineage-specific expansions. An array of transcriptional reporters revealed co-expression of all tested targets in the same pharyngeal gland cell. The morphological remodeling of this cell accompanied the evolution of teeth and predation, linking rapid gene turnover with morphological innovations." @default.
- W2980456224 created "2019-10-25" @default.
- W2980456224 creator A5005424529 @default.
- W2980456224 creator A5007037311 @default.
- W2980456224 creator A5018353947 @default.
- W2980456224 creator A5021176235 @default.
- W2980456224 creator A5053991642 @default.
- W2980456224 creator A5072210288 @default.
- W2980456224 creator A5082517282 @default.
- W2980456224 date "2019-10-17" @default.
- W2980456224 modified "2023-10-15" @default.
- W2980456224 title "Conserved nuclear receptors controlling a novel trait target fast-evolving genes expressed in a single cell" @default.
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