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• W2980457945 abstract "BackgroundEnd-induction minimal residual disease (MRD) is the strongest predictor of relapse in paediatric acute lymphoblastic leukaemia (ALL), but an understanding of the biological pathways underlying early treatment response remains elusive. We hypothesized that metabolomic profiling of diagnostic bone marrow plasma could provide insights into the underlying biology of early treatment response and inform treatment strategies for high-risk patients.MethodsWe performed global metabolomic profiling of samples from discovery (N = 93) and replication (N = 62) cohorts treated at Texas Children's Hospital. Next, we tested the cytotoxicity of drugs targeting central carbon metabolism in cell lines and patient-derived xenograft (PDX) cells.FindingsMetabolite set enrichment analysis identified altered central carbon and amino acid metabolism in MRD-positive patients from both cohorts at a 5% false discovery rate. Metabolites from these pathways were used as inputs for unsupervised hierarchical clustering. Two distinct clusters were identified, which were independently associated with MRD after adjustment for immunophenotype, cytogenetics, and NCI risk group. Three nicotinamide phosphoribosyltransferase (NAMPT) inhibitors, which reduce glycolytic/TCA cycle activities, demonstrated nanomolar-range cytotoxicity in B- and T-ALL cell lines and PDX cells.InterpretationThis study provides new insights into the role of central carbon metabolism in early treatment response and as a potential targetable pathway in high-risk disease.FundingAmerican Society of Hematology; Baylor College of Medicine Department of Paediatrics; Cancer Prevention and Research Institute of Texas; the Lynch family; St. Baldrick's Foundation with support from the Micaela's Army Foundation; United States National Institutes of Health." @default.
• W2980457945 created "2019-10-25" @default.
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• W2980457945 date "2019-10-01" @default.
• W2980457945 modified "2023-09-25" @default.
• W2980457945 title "Metabolomic profiling identifies pathways associated with minimal residual disease in childhood acute lymphoblastic leukaemia" @default.
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• W2980457945 doi "https://doi.org/10.1016/j.ebiom.2019.09.033" @default.
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