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- W2980461187 abstract "Aim To detect the frequency of sonographic fatty liver changes among overweight and obese children and adolescent in the local population. To study the association between anthropometric measurements and biochemical profile and occurrence of NASH. Methods A cross-sectional study, conducted from June 2015 to May 2017 in a tertiary care hospital in South India. Anthropometric data, blood pressure, Ultrasonographic grading for fatty liver, fasting blood sugar, fasting Insulin, Fasting lipid profile, Liver function test, TSH and FT4 were collected for all subjects. HOMA-IR and Fasting glucose insulin ratio (FGIR) were calculated for insulin resistance. SGOT and SGPT>40 IU/ml was considered as abnormal. Height, weight, BMI and waist circumference was converted to SD scoring for analysis. Data was analysed using SPSS v16. Results Twenty seven (25%) children had ultrasonographic evidence of NASH. No significant differences were observed in the occurrence of NASH with age, gender, pubertal status, impaired fasting glucose, abnormal lipid profile, hypertension and metabolic syndrome. Twenty five (92.6% Vs 7.4%; P 0.007) out of twenty seven children with NASH had high waist circumference (according to Indian waist circumference charts). Among children with NASH, only ten had elevated liver enzymes (37%). Children with NASH had significantly higher mean weight SDS (2.35 Vs 1.69, p Conclusions In the study population occurrence of NASH was found to be 25%. The study observed weight SDS as a single most risk factor influencing occurrence of NASH and elevation of SGPT is the single most biochemical parameter correlating with NASH." @default.
- W2980461187 created "2019-10-25" @default.
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- W2980461187 date "2019-05-01" @default.
- W2980461187 modified "2023-09-26" @default.
- W2980461187 title "G583(P) Non alcoholic steatohepatitis in overweight and obese children and its association with anthropometric and metabolic risk factors" @default.
- W2980461187 doi "https://doi.org/10.1136/archdischild-2019-rcpch.564" @default.
- W2980461187 hasPublicationYear "2019" @default.
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