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- W2980469091 abstract "This expert review offers a critical synthesis of the latest insights and approaches at targeting the Wnt/β-catenin pathway in various cancers such as colorectal cancer, melanoma, leukemia, and breast and lung cancers. Notably, from organogenesis to cancer, the Wnt/β-catenin signaling displays varied and highly versatile biological functions in animals, with virtually all tissues requiring the Wnt/β-catenin signaling in one way or the other. Aberrant expression of the members of the Wnt/β-catenin has been implicated in many pathological conditions, particularly in human cancers. Mutations in the Wnt/β-catenin pathway genes have been noted in diverse cancers. Biochemical and genetic data support the idea that inhibition of Wnt/β-catenin signaling is beneficial in cancer therapeutics. The interaction of this important pathway with other signaling systems is also noteworthy, but remains as an area for further research and discovery. In addition, formation of different complexes by components of the Wnt/β-catenin pathway and the precise roles of these complexes in the cytoplasmic milieu are yet to be fully elucidated. This article highlights the latest medical technologies in imaging, single-cell omics, use of artificial intelligence (e.g., machine learning techniques), genome sequencing, quantum computing, molecular docking, and computational softwares in modeling interactions between molecules and predicting protein–protein and compound–protein interactions pertinent to the biology and therapeutic value of the Wnt/β-catenin signaling pathway. We discuss these emerging technologies in relationship to what is currently needed to move from concept to actionable strategies in translating the Wnt/β-catenin laboratory discoveries to Wnt-targeted cancer therapies and diagnostics in the clinic." @default.
- W2980469091 created "2019-10-25" @default.
- W2980469091 creator A5036297031 @default.
- W2980469091 creator A5060709761 @default.
- W2980469091 creator A5081223166 @default.
- W2980469091 date "2019-11-01" @default.
- W2980469091 modified "2023-09-23" @default.
- W2980469091 title "Targeting the Versatile Wnt/β-Catenin Pathway in Cancer Biology and Therapeutics: From Concept to Actionable Strategy" @default.
- W2980469091 cites W1498931318 @default.
- W2980469091 cites W1557541313 @default.
- W2980469091 cites W1586218645 @default.
- W2980469091 cites W1701091641 @default.
- W2980469091 cites W1741548448 @default.
- W2980469091 cites W1749615522 @default.
- W2980469091 cites W1780096456 @default.
- W2980469091 cites W1798211820 @default.
- W2980469091 cites W1802273768 @default.
- W2980469091 cites W1880424969 @default.
- W2980469091 cites W1900557155 @default.
- W2980469091 cites W1923089477 @default.
- W2980469091 cites W1963965802 @default.
- W2980469091 cites W1964129602 @default.
- W2980469091 cites W1964871262 @default.
- W2980469091 cites W1965157206 @default.
- W2980469091 cites W1966824782 @default.
- W2980469091 cites W1967137553 @default.
- W2980469091 cites W1968064237 @default.
- W2980469091 cites W1968665517 @default.
- W2980469091 cites W1969032952 @default.
- W2980469091 cites W1969556504 @default.
- W2980469091 cites W1969607893 @default.
- W2980469091 cites W1969939160 @default.
- W2980469091 cites W1971085650 @default.
- W2980469091 cites W1971402898 @default.
- W2980469091 cites W1971958889 @default.
- W2980469091 cites W1974094726 @default.
- W2980469091 cites W1974595623 @default.
- W2980469091 cites W1974714162 @default.
- W2980469091 cites W1975361178 @default.
- W2980469091 cites W1976411071 @default.
- W2980469091 cites W1977462853 @default.
- W2980469091 cites W1977574907 @default.
- W2980469091 cites W1978871305 @default.
- W2980469091 cites W1982451136 @default.
- W2980469091 cites W1982603620 @default.
- W2980469091 cites W1983253019 @default.
- W2980469091 cites W1983567075 @default.
- W2980469091 cites W1985199900 @default.
- W2980469091 cites W1985359896 @default.
- W2980469091 cites W1986878920 @default.
- W2980469091 cites W1987073253 @default.
- W2980469091 cites W1987074443 @default.
- W2980469091 cites W1987325953 @default.
- W2980469091 cites W1987440530 @default.
- W2980469091 cites W1988075836 @default.
- W2980469091 cites W1989194294 @default.
- W2980469091 cites W1989215255 @default.
- W2980469091 cites W1991692366 @default.
- W2980469091 cites W1992646456 @default.
- W2980469091 cites W1994029539 @default.
- W2980469091 cites W1994518306 @default.
- W2980469091 cites W1994928797 @default.
- W2980469091 cites W1996900960 @default.
- W2980469091 cites W1999408122 @default.
- W2980469091 cites W1999423655 @default.
- W2980469091 cites W2000042026 @default.
- W2980469091 cites W2000293457 @default.
- W2980469091 cites W2000467897 @default.
- W2980469091 cites W2006419043 @default.
- W2980469091 cites W2007717461 @default.
- W2980469091 cites W2009684443 @default.
- W2980469091 cites W2012087132 @default.
- W2980469091 cites W2013469946 @default.
- W2980469091 cites W2013891209 @default.
- W2980469091 cites W2014260136 @default.
- W2980469091 cites W2015200944 @default.
- W2980469091 cites W2016373982 @default.
- W2980469091 cites W2017668082 @default.
- W2980469091 cites W2017729871 @default.
- W2980469091 cites W2017912617 @default.
- W2980469091 cites W2018602900 @default.
- W2980469091 cites W2019544036 @default.
- W2980469091 cites W2022488821 @default.
- W2980469091 cites W2023192965 @default.
- W2980469091 cites W2024447346 @default.
- W2980469091 cites W2026650776 @default.
- W2980469091 cites W2027150010 @default.
- W2980469091 cites W2028243804 @default.
- W2980469091 cites W2029056144 @default.
- W2980469091 cites W2029437539 @default.
- W2980469091 cites W2029824690 @default.
- W2980469091 cites W2030181973 @default.
- W2980469091 cites W2031522329 @default.
- W2980469091 cites W2032430075 @default.
- W2980469091 cites W2033104963 @default.
- W2980469091 cites W2033106726 @default.
- W2980469091 cites W2034373020 @default.
- W2980469091 cites W2034437737 @default.