Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980471831> ?p ?o ?g. }
- W2980471831 endingPage "194" @default.
- W2980471831 startingPage "186" @default.
- W2980471831 abstract "Morphine is the opioid most commonly used for neonatal pain management. In intravenous form, it is administered as continuous infusions and intermittent injections, mostly based on empirically established protocols. Inadequate pain control in neonates can cause long‐term adverse consequences; however, providing appropriate individualized morphine dosing is particularly challenging due to the interplay of rapid natural physiological changes and multiple life‐sustaining procedures in patients who cannot describe their symptoms. At most institutions, morphine dosing in neonates is largely carried out as an iterative process using a wide range of starting doses and then titrating to effect based on clinical response and side effects using pain scores and levels of sedation. Our background data show that neonates exhibit large variability in morphine clearance resulting in a wide range of exposures, which are poorly predicted by dose alone. Here, we describe the development and implementation of an electronic health record–integrated, model‐informed decision support platform for the precision dosing of morphine in the management of neonatal pain. The platform supports pharmacokinetic model‐informed dosing guidance and has functionality to incorporate real‐time drug concentration information. The feedback is inserted directly into prescribers' workflows so that they can make data‐informed decisions. The expected outcomes are better clinical efficacy and safety with fewer side effects in the neonatal population." @default.
- W2980471831 created "2019-10-25" @default.
- W2980471831 creator A5004052078 @default.
- W2980471831 creator A5005369648 @default.
- W2980471831 creator A5016058238 @default.
- W2980471831 creator A5017085550 @default.
- W2980471831 creator A5020064054 @default.
- W2980471831 creator A5029917903 @default.
- W2980471831 creator A5030702136 @default.
- W2980471831 creator A5033398082 @default.
- W2980471831 creator A5036804110 @default.
- W2980471831 creator A5038084054 @default.
- W2980471831 creator A5040060343 @default.
- W2980471831 creator A5060361002 @default.
- W2980471831 creator A5070476286 @default.
- W2980471831 creator A5071907067 @default.
- W2980471831 creator A5077150971 @default.
- W2980471831 creator A5083752494 @default.
- W2980471831 date "2019-12-11" @default.
- W2980471831 modified "2023-09-26" @default.
- W2980471831 title "Electronic Health Record–Embedded Decision Support Platform for Morphine Precision Dosing in Neonates" @default.
- W2980471831 cites W1507278289 @default.
- W2980471831 cites W1570325828 @default.
- W2980471831 cites W1907667216 @default.
- W2980471831 cites W1964582565 @default.
- W2980471831 cites W1969252821 @default.
- W2980471831 cites W1980803111 @default.
- W2980471831 cites W1992237316 @default.
- W2980471831 cites W1996822698 @default.
- W2980471831 cites W1999956272 @default.
- W2980471831 cites W2006867331 @default.
- W2980471831 cites W2011450961 @default.
- W2980471831 cites W2023174165 @default.
- W2980471831 cites W2045883317 @default.
- W2980471831 cites W2073866110 @default.
- W2980471831 cites W2075435606 @default.
- W2980471831 cites W2093495032 @default.
- W2980471831 cites W2100782598 @default.
- W2980471831 cites W2121696198 @default.
- W2980471831 cites W2123589913 @default.
- W2980471831 cites W2124677775 @default.
- W2980471831 cites W2154634960 @default.
- W2980471831 cites W2159764323 @default.
- W2980471831 cites W2237511635 @default.
- W2980471831 cites W2461643509 @default.
- W2980471831 cites W2545205459 @default.
- W2980471831 cites W2560422329 @default.
- W2980471831 cites W2725542954 @default.
- W2980471831 cites W2766856975 @default.
- W2980471831 cites W2768032427 @default.
- W2980471831 cites W2891475319 @default.
- W2980471831 cites W2896572723 @default.
- W2980471831 cites W2927113774 @default.
- W2980471831 cites W4233740607 @default.
- W2980471831 cites W973722855 @default.
- W2980471831 doi "https://doi.org/10.1002/cpt.1684" @default.
- W2980471831 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7378965" @default.
- W2980471831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31618453" @default.
- W2980471831 hasPublicationYear "2019" @default.
- W2980471831 type Work @default.
- W2980471831 sameAs 2980471831 @default.
- W2980471831 citedByCount "28" @default.
- W2980471831 countsByYear W29804718312019 @default.
- W2980471831 countsByYear W29804718312020 @default.
- W2980471831 countsByYear W29804718312021 @default.
- W2980471831 countsByYear W29804718312022 @default.
- W2980471831 countsByYear W29804718312023 @default.
- W2980471831 crossrefType "journal-article" @default.
- W2980471831 hasAuthorship W2980471831A5004052078 @default.
- W2980471831 hasAuthorship W2980471831A5005369648 @default.
- W2980471831 hasAuthorship W2980471831A5016058238 @default.
- W2980471831 hasAuthorship W2980471831A5017085550 @default.
- W2980471831 hasAuthorship W2980471831A5020064054 @default.
- W2980471831 hasAuthorship W2980471831A5029917903 @default.
- W2980471831 hasAuthorship W2980471831A5030702136 @default.
- W2980471831 hasAuthorship W2980471831A5033398082 @default.
- W2980471831 hasAuthorship W2980471831A5036804110 @default.
- W2980471831 hasAuthorship W2980471831A5038084054 @default.
- W2980471831 hasAuthorship W2980471831A5040060343 @default.
- W2980471831 hasAuthorship W2980471831A5060361002 @default.
- W2980471831 hasAuthorship W2980471831A5070476286 @default.
- W2980471831 hasAuthorship W2980471831A5071907067 @default.
- W2980471831 hasAuthorship W2980471831A5077150971 @default.
- W2980471831 hasAuthorship W2980471831A5083752494 @default.
- W2980471831 hasBestOaLocation W29804718312 @default.
- W2980471831 hasConcept C126322002 @default.
- W2980471831 hasConcept C170493617 @default.
- W2980471831 hasConcept C177713679 @default.
- W2980471831 hasConcept C1862650 @default.
- W2980471831 hasConcept C197934379 @default.
- W2980471831 hasConcept C2776814716 @default.
- W2980471831 hasConcept C2777288759 @default.
- W2980471831 hasConcept C2777389121 @default.
- W2980471831 hasConcept C2781063702 @default.
- W2980471831 hasConcept C2781118164 @default.
- W2980471831 hasConcept C2908647359 @default.
- W2980471831 hasConcept C42219234 @default.
- W2980471831 hasConcept C71924100 @default.