Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980473693> ?p ?o ?g. }
- W2980473693 endingPage "942" @default.
- W2980473693 startingPage "934" @default.
- W2980473693 abstract "Abstract Background The human hookworm, Necator americanus, is a parasite that infects almost half a billion people worldwide. Although treatment is available, vaccination is favorable to combat the spread of this parasite due to its wide distribution and continuous reinfection cycle in endemic communities. Methods We have designed a lipopeptide oral delivery system using a B-cell epitope derived from the aspartic protease Na-APR-1 from N americanus, attached to a T-helper epitope. Lipopeptides were self-assembled into nanoparticles or entrapped in liposomes that were electrostatically coated with alginate and trimethyl chitosan polymer shields. The adjuvant-free vaccine candidates were orally administered to mice and generated a humoral immune response against both peptide antigen, and the parent protein in the hookworm gut. Results The vaccine candidates were evaluated in a rodent hookworm challenge model, resulting in up to 98% and 99% decreases in mean intestinal worm and egg burdens in immunized mice, respectively. Conclusions Lipopeptide survived the gastrointestinal conditions, induced humoral immune responses and drived protection against parasite challenge infection." @default.
- W2980473693 created "2019-10-25" @default.
- W2980473693 creator A5005939079 @default.
- W2980473693 creator A5008581557 @default.
- W2980473693 creator A5008664953 @default.
- W2980473693 creator A5017796147 @default.
- W2980473693 creator A5024270822 @default.
- W2980473693 creator A5028490375 @default.
- W2980473693 creator A5080081292 @default.
- W2980473693 creator A5084069127 @default.
- W2980473693 creator A5089357963 @default.
- W2980473693 date "2019-10-17" @default.
- W2980473693 modified "2023-09-24" @default.
- W2980473693 title "Lipopeptide-Based Oral Vaccine Against Hookworm Infection" @default.
- W2980473693 cites W1871591691 @default.
- W2980473693 cites W1968419962 @default.
- W2980473693 cites W1972187290 @default.
- W2980473693 cites W1975709358 @default.
- W2980473693 cites W1978322762 @default.
- W2980473693 cites W1982312828 @default.
- W2980473693 cites W1985177867 @default.
- W2980473693 cites W1994667037 @default.
- W2980473693 cites W2009439501 @default.
- W2980473693 cites W2015497529 @default.
- W2980473693 cites W2016150993 @default.
- W2980473693 cites W2019539444 @default.
- W2980473693 cites W2026505420 @default.
- W2980473693 cites W2061510929 @default.
- W2980473693 cites W2097727405 @default.
- W2980473693 cites W2109482774 @default.
- W2980473693 cites W2109598625 @default.
- W2980473693 cites W2110443462 @default.
- W2980473693 cites W2114559618 @default.
- W2980473693 cites W2129629034 @default.
- W2980473693 cites W2134897517 @default.
- W2980473693 cites W2151211884 @default.
- W2980473693 cites W2151957316 @default.
- W2980473693 cites W2158587710 @default.
- W2980473693 cites W2162870507 @default.
- W2980473693 cites W2172014372 @default.
- W2980473693 cites W2172246547 @default.
- W2980473693 cites W2290466312 @default.
- W2980473693 cites W2327171017 @default.
- W2980473693 cites W2329794401 @default.
- W2980473693 cites W2332692713 @default.
- W2980473693 cites W2338147075 @default.
- W2980473693 cites W2418712064 @default.
- W2980473693 cites W2419196011 @default.
- W2980473693 cites W2489429113 @default.
- W2980473693 cites W2509632222 @default.
- W2980473693 cites W2512896817 @default.
- W2980473693 cites W2520461672 @default.
- W2980473693 cites W2566687857 @default.
- W2980473693 cites W2668780319 @default.
- W2980473693 cites W2790971883 @default.
- W2980473693 cites W2898807570 @default.
- W2980473693 cites W2918249593 @default.
- W2980473693 cites W4210971000 @default.
- W2980473693 doi "https://doi.org/10.1093/infdis/jiz528" @default.
- W2980473693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31621864" @default.
- W2980473693 hasPublicationYear "2019" @default.
- W2980473693 type Work @default.
- W2980473693 sameAs 2980473693 @default.
- W2980473693 citedByCount "34" @default.
- W2980473693 countsByYear W29804736932020 @default.
- W2980473693 countsByYear W29804736932021 @default.
- W2980473693 countsByYear W29804736932022 @default.
- W2980473693 countsByYear W29804736932023 @default.
- W2980473693 crossrefType "journal-article" @default.
- W2980473693 hasAuthorship W2980473693A5005939079 @default.
- W2980473693 hasAuthorship W2980473693A5008581557 @default.
- W2980473693 hasAuthorship W2980473693A5008664953 @default.
- W2980473693 hasAuthorship W2980473693A5017796147 @default.
- W2980473693 hasAuthorship W2980473693A5024270822 @default.
- W2980473693 hasAuthorship W2980473693A5028490375 @default.
- W2980473693 hasAuthorship W2980473693A5080081292 @default.
- W2980473693 hasAuthorship W2980473693A5084069127 @default.
- W2980473693 hasAuthorship W2980473693A5089357963 @default.
- W2980473693 hasConcept C147483822 @default.
- W2980473693 hasConcept C159047783 @default.
- W2980473693 hasConcept C159654299 @default.
- W2980473693 hasConcept C165901193 @default.
- W2980473693 hasConcept C195616568 @default.
- W2980473693 hasConcept C203014093 @default.
- W2980473693 hasConcept C22070199 @default.
- W2980473693 hasConcept C2776677957 @default.
- W2980473693 hasConcept C2777047024 @default.
- W2980473693 hasConcept C2777364306 @default.
- W2980473693 hasConcept C2777425210 @default.
- W2980473693 hasConcept C2777863537 @default.
- W2980473693 hasConcept C523546767 @default.
- W2980473693 hasConcept C54355233 @default.
- W2980473693 hasConcept C86803240 @default.
- W2980473693 hasConcept C8891405 @default.
- W2980473693 hasConcept C89423630 @default.
- W2980473693 hasConceptScore W2980473693C147483822 @default.
- W2980473693 hasConceptScore W2980473693C159047783 @default.
- W2980473693 hasConceptScore W2980473693C159654299 @default.