FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980478025> ?p ?o ?g. }

• W2980478025 endingPage "3751" @default.
• W2980478025 startingPage "3751" @default.
• W2980478025 abstract "Activation of the transcription factor liver X receptor (LXR) has beneficial effects on macrophage lipid metabolism and inflammation, making it a potential candidate for therapeutic targeting in cardiometabolic disease. While small molecule delivery via nanomedicine has promising applications for a number of chronic diseases, questions remain as to how nanoparticle formulation might be tailored to suit different tissue microenvironments and aid in drug delivery. In the current study, we aimed to compare the in vitro drug delivering capability of three nanoparticle (NP) formulations encapsulating the LXR activator, GW-3965. We observed little difference in the base characteristics of standard PLGA-PEG NP when compared to two redox-active polymeric NP formulations, which we called redox-responsive (RR)1 and RR2. Moreover, we also observed similar uptake of these NP into primary mouse macrophages. We used the transcript and protein expression of the cholesterol efflux protein and LXR target ATP-binding cassette A1 (ABCA1) as a readout of GW-3956-induced LXR activation. Following an initial acute uptake period that was meant to mimic circulating exposure in vivo, we determined that although the induction of transcript expression was similar between NPs, treatment with the redox-sensitive RR1 NPs resulted in a higher level of ABCA1 protein. Our results suggest that NP formulations responsive to cellular cues may be an effective tool for targeted and disease-specific drug release." @default.
• W2980478025 created "2019-10-25" @default.
• W2980478025 creator A5001289581 @default.
• W2980478025 creator A5042795468 @default.
• W2980478025 creator A5063568342 @default.
• W2980478025 creator A5073546451 @default.
• W2980478025 creator A5076466872 @default.
• W2980478025 creator A5081766701 @default.
• W2980478025 creator A5082662070 @default.
• W2980478025 creator A5083997128 @default.
• W2980478025 creator A5086957322 @default.
• W2980478025 date "2019-10-18" @default.
• W2980478025 modified "2023-10-14" @default.
• W2980478025 title "Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages" @default.
• W2980478025 cites W1755513170 @default.
• W2980478025 cites W1964064254 @default.
• W2980478025 cites W1970329005 @default.
• W2980478025 cites W1977074396 @default.
• W2980478025 cites W2005347748 @default.
• W2980478025 cites W2005911243 @default.
• W2980478025 cites W2019544413 @default.
• W2980478025 cites W2028481823 @default.
• W2980478025 cites W2040274922 @default.
• W2980478025 cites W2052909312 @default.
• W2980478025 cites W2058205407 @default.
• W2980478025 cites W2059904244 @default.
• W2980478025 cites W2096171994 @default.
• W2980478025 cites W2104016841 @default.
• W2980478025 cites W2107277218 @default.
• W2980478025 cites W2127410754 @default.
• W2980478025 cites W2128094952 @default.
• W2980478025 cites W2130166533 @default.
• W2980478025 cites W2133718879 @default.
• W2980478025 cites W2143786800 @default.
• W2980478025 cites W2153673003 @default.
• W2980478025 cites W2156331399 @default.
• W2980478025 cites W2159332620 @default.
• W2980478025 cites W2160654483 @default.
• W2980478025 cites W2164516421 @default.
• W2980478025 cites W2173359203 @default.
• W2980478025 cites W2192080449 @default.
• W2980478025 cites W2199589899 @default.
• W2980478025 cites W2257033524 @default.
• W2980478025 cites W2319556652 @default.
• W2980478025 cites W2487403103 @default.
• W2980478025 cites W2528801719 @default.
• W2980478025 cites W2554773181 @default.
• W2980478025 cites W2621509706 @default.
• W2980478025 cites W2737124267 @default.
• W2980478025 cites W2808212266 @default.
• W2980478025 cites W2885209763 @default.
• W2980478025 cites W2889191136 @default.
• W2980478025 cites W2893445622 @default.
• W2980478025 cites W2945659966 @default.
• W2980478025 cites W2956215750 @default.
• W2980478025 cites W2969488042 @default.
• W2980478025 cites W4230088158 @default.
• W2980478025 doi "https://doi.org/10.3390/molecules24203751" @default.
• W2980478025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6833070" @default.
• W2980478025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31635211" @default.
• W2980478025 hasPublicationYear "2019" @default.
• W2980478025 type Work @default.
• W2980478025 sameAs 2980478025 @default.
• W2980478025 citedByCount "6" @default.
• W2980478025 countsByYear W29804780252020 @default.
• W2980478025 countsByYear W29804780252021 @default.
• W2980478025 countsByYear W29804780252022 @default.
• W2980478025 crossrefType "journal-article" @default.
• W2980478025 hasAuthorship W2980478025A5001289581 @default.
• W2980478025 hasAuthorship W2980478025A5042795468 @default.
• W2980478025 hasAuthorship W2980478025A5063568342 @default.
• W2980478025 hasAuthorship W2980478025A5073546451 @default.
• W2980478025 hasAuthorship W2980478025A5076466872 @default.
• W2980478025 hasAuthorship W2980478025A5081766701 @default.
• W2980478025 hasAuthorship W2980478025A5082662070 @default.
• W2980478025 hasAuthorship W2980478025A5083997128 @default.
• W2980478025 hasAuthorship W2980478025A5086957322 @default.
• W2980478025 hasBestOaLocation W29804780251 @default.
• W2980478025 hasConcept C104317684 @default.
• W2980478025 hasConcept C149011108 @default.
• W2980478025 hasConcept C150903083 @default.
• W2980478025 hasConcept C167400880 @default.
• W2980478025 hasConcept C170493617 @default.
• W2980478025 hasConcept C178790620 @default.
• W2980478025 hasConcept C185592680 @default.
• W2980478025 hasConcept C207001950 @default.
• W2980478025 hasConcept C2777704780 @default.
• W2980478025 hasConcept C2779820397 @default.
• W2980478025 hasConcept C55493867 @default.
• W2980478025 hasConcept C63932345 @default.
• W2980478025 hasConcept C86339819 @default.
• W2980478025 hasConcept C86803240 @default.
• W2980478025 hasConcept C88045685 @default.
• W2980478025 hasConcept C95444343 @default.
• W2980478025 hasConcept C98274493 @default.
• W2980478025 hasConceptScore W2980478025C104317684 @default.
• W2980478025 hasConceptScore W2980478025C149011108 @default.
• W2980478025 hasConceptScore W2980478025C150903083 @default.

• next