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• W2980479149 abstract "SESSION TITLE: Wednesday Fellows Case Report Posters SESSION TYPE: Fellow Case Report Posters PRESENTED ON: 10/23/2019 09:45 AM - 10:45 AM INTRODUCTION: Pulmonary hypertension (PH) is a disease characterized by a mean pulmonary artery pressure (PAP) of more than 25 mmHg at rest, pulmonary artery wedge pressure less than 15 mmHg, and pulmonary vascular resistance more than 3 Wood units. The World Health Organization classifies PH into 5 different groups based on etiology. Here we present a case report of a patient with thyrotoxicosis induced PH. CASE PRESENTATION: A 51-year-old male with a past medical history of hypertension and hyperthyroidism presented to the emergency department with progressive shortness of breath and lower extremity edema of several months’ duration. Upon arrival, the patient’s vitals revealed tachycardia, hypoxemia and hypertension. It was noted that the patient was previously treated for hyperthyroidism but had discontinued his medications. Initial laboratory analysis revealed thyroid-stimulating hormone (TSH) DISCUSSION: Literature review reveals several case reports of thyrotoxicosis as the underlying cause of pulmonary hypertension. Thyrotoxicosis, a severe form of hyperthyroidism, is associated with sinus tachycardia, atrial arrhythmias, and high-output cardiac failure which can all lead to pulmonary hypertension. While the exact pathogenesis remains a debate, a strong association between TSH values and pulmonary arterial pressures has been noted. Patients in a euthyroid state as a result of antithyroid therapy have exhibited normal pulmonary arterial pressures. Treatment of hyperthyroidism induced pulmonary hypertension is aimed at the underlying disorder as well as right ventricular dysfunction (i.e. oxygen and diuretic therapy). If appropriate therapy is initiated, symptom improvement and/or resolution is expected. CONCLUSIONS: Hyperthyroidism is a cause of group 5 pulmonary hypertension. Treatment of hyperthyroidism induced pulmonary hypertension is aimed at the underlying disorder as well as right ventricular dysfunction. If appropriate therapy is initiated, symptom improvement and/or resolution is expected. Reference #1: Rubin LJ; Physicians ACoC. Diagnosis and management of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004; 126(1 Suppl): 7S–10S. [PubMed] Reference #2: Marvisi M, Brianti M, Marani G, et al. Hyperthyroidism and pulmonary hypertension. Respir Med. 2002;96:215-220. Reference #3: Rich S (ed). Executive summary from the World Symposium on Primary Pulmonary Hypertension, Evian, France, September 6-10, 1998, co-sponsored by The World Health Organization. DISCLOSURES: No relevant relationships by Daniel Griffin, source=Web Response No relevant relationships by Parth Patel, source=Web Response" @default.
• W2980479149 created "2019-10-25" @default.
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• W2980479149 date "2019-10-01" @default.
• W2980479149 modified "2023-09-25" @default.
• W2980479149 title "HYPERTHYROIDISM-INDUCED PULMONARY HYPERTENSION" @default.
• W2980479149 doi "https://doi.org/10.1016/j.chest.2019.08.1631" @default.
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