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- W2980479938 abstract "Especially since the transfer of chimeric antigen receptor (CAR) T cell therapy to the clinic, there has been controversy over the amount of target molecules necessary to activate T cells via a CAR. Here, we evaluate the use of CAR-modified T-cells targeting CD19 (CD19CART) in multiple myeloma. A highly recognized study (Garfall et al, NEJM 2015) reported complete remission in one patient that had received CD19CART, even though only 0.05% of myeloma cells expressed CD19 as judged by flow cytometry (FC). This has sparked debate over low level CD19 expression on myeloma cells that may be invisible to detection via FC but could trigger elimination by CD19CART." @default.
- W2980479938 created "2019-10-25" @default.
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- W2980479938 date "2019-10-01" @default.
- W2980479938 modified "2023-10-16" @default.
- W2980479938 title "Super-resolution microscopy reveals ultra-low expression of CD19 on myeloma cells that triggers elimination by CAR-T cells" @default.
- W2980479938 doi "https://doi.org/10.1016/j.clml.2019.09.277" @default.
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