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- W2980490902 abstract "Abstract Three-dimensional genome organisation and replication timing are known to be correlated, however, it remains unknown whether nuclear architecture overall plays an instructive role in the replication-timing program and, if so, how. Here we demonstrate that RIF1 is a molecular hub that co-regulates both processes. Both nuclear organisation and replication timing depend upon the interaction between RIF1 and PP1. However, whereas nuclear architecture requires the full complement of RIF1 and its interaction with PP1, replication timing is not sensitive to RIF1 dosage. RIF1’s role in replication timing also extends beyond its interaction with PP1. Availing of this separation-of-function approach, we have therefore identified in RIF1 dual function the molecular bases of the co-dependency of the replication-timing program and nuclear architecture." @default.
- W2980490902 created "2019-10-25" @default.
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- W2980490902 date "2019-10-21" @default.
- W2980490902 modified "2023-10-16" @default.
- W2980490902 title "Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction" @default.
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- W2980490902 cites W1971045116 @default.
- W2980490902 cites W1988745695 @default.
- W2980490902 cites W1997462031 @default.
- W2980490902 cites W2000625991 @default.
- W2980490902 cites W2000830981 @default.
- W2980490902 cites W2024406051 @default.
- W2980490902 cites W2026842770 @default.
- W2980490902 cites W2032949964 @default.
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- W2980490902 cites W2053674184 @default.
- W2980490902 cites W2055671516 @default.
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- W2980490902 cites W2064537118 @default.
- W2980490902 cites W2070046136 @default.
- W2980490902 cites W2078438237 @default.
- W2980490902 cites W2096391864 @default.
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- W2980490902 cites W2146667434 @default.
- W2980490902 cites W2148744078 @default.
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- W2980490902 cites W2163649668 @default.
- W2980490902 cites W2164912629 @default.
- W2980490902 cites W2169047304 @default.
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- W2980490902 cites W2289400000 @default.
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- W2980490902 cites W2404630957 @default.
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- W2980490902 cites W2763962307 @default.
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- W2980490902 doi "https://doi.org/10.1101/812156" @default.
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