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- W2980491583 abstract "Few community-based studies have enough autopsies to study the pattern of mixed pathologies over small intervals of age, or how age-related patterns relate to cognitive status. We extend our previous work utilizing autopsies from a large community-based cohort and the most up-to-date catalog of dementia-related neuropathologies. Data came from the Rush Memory and Aging Project and the Religious Orders Study, including clinical evaluations using standard criteria for dementia and mild cognitive impairment (MCI), and detailed neuropathological examination to identify pathologic diagnosis of AD (NIA-Reagan criteria), presence of neocortical Lewy bodies (LB), TDP-43 pathology extending beyond the amygdala, hippocampal sclerosis (HS), and vascular pathologies (multiple macroinfarcts or cortical microinfarcts, moderate to severe atherosclerosis, arteriolosclerosis, or cerebral amyloid angiopathy). Persons were grouped based on age-at-death; <80 (n=95), 80–84 (n=176), 85–89 (n=328), 90–94 (n=377), 95–99 (n=200), and 100+ (n=61). Analyses included tests for trend and log-binomial regression models. Of 1,237 participants, 515 had dementia, 293 had MCI, and 429 had normal cognition proximate to death (mean 11 months before autopsy). Proportion of mixed pathologies was lowest (28%) in the youngest group and highest (69%) in the oldest (p-trend <0.001), while proportion with isolated AD pathology did not vary (<10%, p-trend=0.72). In those with normal cognition, proportions with mixed pathologies ranged from 19% (youngest) to 54% (oldest) (p-trend<0.001); there was no significant difference by age group in the MCI group (p-trend=0.06) or dementia group (73%-79%, p-trend=0.49). Observing specific combinations of pathologies in the total group, AD+Lewy bodies did not vary across age groups (3%-8%, p-trend=0.56); however, while proportions with AD+TDP-43/HS (4%-43%, p-trend<0.001) and AD+vascular (24%-66%, p-trend<0.001) did. In interaction models adjusted for sex, education, and other pathologies, the association between each mixed pathology combination and dementia was attenuated at higher ages." @default.
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- W2980491583 date "2019-07-01" @default.
- W2980491583 modified "2023-09-27" @default.
- W2980491583 title "P1-435: PATTERN OF MIXED PATHOLOGIES BY AGE AND RELATIONSHIP TO DEMENTIA AND MCI IN COMMUNITY-BASED COHORTS" @default.
- W2980491583 doi "https://doi.org/10.1016/j.jalz.2019.06.1040" @default.
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