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- W2980493401 endingPage "8963" @default.
- W2980493401 startingPage "8947" @default.
- W2980493401 abstract "E-cadherin is well known as a growth and invasion suppressor and belongs to the large cadherin family. Loss of E-cadherin is widely known as the hallmark of epithelial-to-mesenchymal transition (EMT) with the involvement of transcription factors such as Snail, Slug, Twist and Zeb1/2. Tumor cells undergoing EMT could migrate to distant sites and become metastases. Recently, numerous studies have revealed how the expression of E-cadherin is regulated by different kinds of genetic and epigenetic alteration, which are implicated in several crucial transcription factors and pathways. E-cadherin signaling plays an important role in hepatocellular carcinoma (HCC) initiation and progression considering the highly mutated frequency of CTNNB1 (27%). Combining the data from The Cancer Genome Atlas (TCGA) database and previous studies, we have summarized the roles of gene mutations, chromosome instability, DNA methylation, histone modifications and non-coding RNA in E-cadherin in HCC. In this review, we discuss the current understanding of the relationship between these modifications and HCC. Perspectives on E-cadherin-related research in HCC are provided." @default.
- W2980493401 created "2019-10-25" @default.
- W2980493401 creator A5001097998 @default.
- W2980493401 creator A5029363653 @default.
- W2980493401 creator A5035742116 @default.
- W2980493401 creator A5058898772 @default.
- W2980493401 creator A5060364374 @default.
- W2980493401 creator A5080799590 @default.
- W2980493401 creator A5090305166 @default.
- W2980493401 creator A5091564422 @default.
- W2980493401 date "2019-10-01" @default.
- W2980493401 modified "2023-10-18" @default.
- W2980493401 title "<p>Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma</p>" @default.
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