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- W2980494754 abstract "White matter hyperintensities (WMH) have been extensively associated with cognitive impairment and reductions in gray matter volume (GMv) independently. This study explored whether WMH volume mediates the relationship between GMv and cognition voxel-wise in cognitively unimpaired middle-aged individuals. Episodic memory (EM) was measured by the Memory Binding Test (MBT) and executive functions (EF) using five WAIS-IV subtests in 521 middle-aged (mean age 57.7 years) cognitively unimpaired individuals of the ALFA cohort [1] who underwent MRI. WMH were automatically segmented [2] from T2 and FLAIR sequences and characterized using diffusion-weighted imaging (DWI) parameters. A voxel-wise mediation analysis was performed. This analysis partitions the association between X and Y (total effect=c) into two components: one mediated by M (indirect effect=ab) and another one independent from M (direct effect=c’). The relationship between GMv (X) and cognitive performance (Y) was studied entering WMH (global and by distance to the ventricle) as a mediator (M) and correcting everything by sociodemographic factors (age, sex and education), APOE-e4 and total intracranial volume. WMH burden was low in this cohort (median=3.2ml). Higher WMH lesion volume was significantly associated to a widespread pattern of lower GMv in temporal (including hippocampus) and frontal areas, as well as in thalamus and cerebellum (Table 1 and Figure 2). DWI diffusivity parameters in WMH were compatible with demyelination and axonal loss. WMH volume significantly mediated the relationship between GMv and brain regions involved in EF performance, but not EM (Table 2 and Figure 2). The behavior of EF composite in temporal and frontal regions was mainly driven by the indirect effects of deep WMH (Figure 3)." @default.
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- W2980494754 date "2019-07-01" @default.
- W2980494754 modified "2023-10-06" @default.
- W2980494754 title "P3-323: WHITE MATTER HYPERINTENSITIES MEDIATE THE RELATIONSHIP BETWEEN GRAY MATTER VOLUME AND EXECUTIVE FUNCTION IN COGNITIVELY UNIMPAIRED MIDDLE-AGED INDIVIDUALS" @default.
- W2980494754 doi "https://doi.org/10.1016/j.jalz.2019.06.3355" @default.
- W2980494754 hasPublicationYear "2019" @default.
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