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- W2980495364 endingPage "184" @default.
- W2980495364 startingPage "169" @default.
- W2980495364 abstract "In the decade since their advent, ablative fractional lasers have emerged as powerful tools to enhance drug delivery to and through the skin. Effective and highly customizable, laser-assisted drug delivery (LADD) has led to improved therapeutic outcomes for several medical indications. However, for LADD to reach maturity as a standard treatment technique, a greater appreciation of its underlying science is needed. This work aims to provide an in-depth guide to the technology's fundamental principles, experimental methodology and unique aspects of LADD data interpretation. We show that drug's physicochemical properties including solubility, molecular weight and tissue binding behavior, are crucial determinants of how laser channel morphology influences topical delivery. Furthermore, we identify strengths and limitations of experimental models and drug detection techniques, interrogating the usefulness of in vitro data in predicting LADD in vivo. By compiling insights from over 75 studies, we ultimately devise an approach for intelligent application of LADD, supporting its implementation in the clinical setting." @default.
- W2980495364 created "2019-10-25" @default.
- W2980495364 creator A5022443356 @default.
- W2980495364 creator A5075551274 @default.
- W2980495364 creator A5086669701 @default.
- W2980495364 date "2020-01-01" @default.
- W2980495364 modified "2023-10-16" @default.
- W2980495364 title "Fundamentals of fractional laser-assisted drug delivery: An in-depth guide to experimental methodology and data interpretation" @default.
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