FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980495663> ?p ?o ?g. }

• W2980495663 endingPage "640" @default.
• W2980495663 startingPage "627" @default.
• W2980495663 abstract "A one-time vancomycin loading dose of 25-30 mg/kg is recommended in the current iteration of the vancomycin consensus guidelines in order to more rapidly achieve target serum concentrations and hasten clinical improvement. However, there are few clinical data to support this practice, and the extents of its benefits are largely unknown.A multicenter, retrospective, cohort study was performed to assess the impact of a vancomycin loading dose (≥ 20 mg/kg) on clinical outcomes and rates of nephrotoxicity in patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. The study matched patients in a 1:1 fashion based on age, Pitt bacteremia score, and bacteremia source. The primary outcome was composite treatment failure (30-day mortality, bacteremia duration ≥ 7 days after vancomycin initiation, persistent signs and symptoms of infection ≥ 7 days after vancomycin initiation, or switch to an alternative antimicrobial agent). Secondary outcomes included duration of bacteremia, length of stay post-bacteremia onset, and nephrotoxicity.A total of 316 patients with MRSA bacteremia were included. Median first doses in the loading dose and non-loading dose groups were 23.0 mg/kg and 14.3 mg/kg, respectively (P < 0.001). No difference was found in composite failure rates between the non-loading dose and loading dose groups (40.5% vs. 36.7%; P = 0.488) or in the incidence of nephrotoxicity (12.7% vs. 16.5%; P = 0.347). While multivariable regression modeling showed receipt of a vancomycin loading dose on a mg/kg basis was not significantly associated with composite failure [aOR 0.612, 95% CI (0.368-1.019)]; post hoc analyses demonstrated that initial doses ≥ 1750 mg were independently protective against failure [aOR 0.506, 95% CI (0.284-0.902)] without increasing the risk for nephrotoxicity [aOR 0.909, 95% CI (0.432-1.911)].These findings suggest that initial vancomycin doses above a certain threshold may decrease clinical failures without increasing toxicity and that weight-based dosing might not be the optimal strategy." @default.
• W2980495663 created "2019-10-25" @default.
• W2980495663 creator A5010659587 @default.
• W2980495663 creator A5012893972 @default.
• W2980495663 creator A5052246119 @default.
• W2980495663 creator A5067362047 @default.
• W2980495663 creator A5070110549 @default.
• W2980495663 creator A5077074926 @default.
• W2980495663 creator A5083261865 @default.
• W2980495663 creator A5084829703 @default.
• W2980495663 date "2019-10-21" @default.
• W2980495663 modified "2023-10-01" @default.
• W2980495663 title "Relationship Status between Vancomycin Loading Dose and Treatment Failure in Patients with MRSA Bacteremia: It’s Complicated" @default.
• W2980495663 cites W1558235154 @default.
• W2980495663 cites W1977408435 @default.
• W2980495663 cites W1977578039 @default.
• W2980495663 cites W2002609036 @default.
• W2980495663 cites W2010066166 @default.
• W2980495663 cites W2037594369 @default.
• W2980495663 cites W2051651842 @default.
• W2980495663 cites W2080176316 @default.
• W2980495663 cites W2108039951 @default.
• W2980495663 cites W2108433768 @default.
• W2980495663 cites W2109144391 @default.
• W2980495663 cites W2111232359 @default.
• W2980495663 cites W2114585210 @default.
• W2980495663 cites W2114889933 @default.
• W2980495663 cites W2133120422 @default.
• W2980495663 cites W2134944593 @default.
• W2980495663 cites W2152771638 @default.
• W2980495663 cites W2180829827 @default.
• W2980495663 cites W2266872140 @default.
• W2980495663 cites W2473016454 @default.
• W2980495663 cites W2521252357 @default.
• W2980495663 cites W2625518087 @default.
• W2980495663 cites W2689001823 @default.
• W2980495663 cites W2765727798 @default.
• W2980495663 cites W2766177920 @default.
• W2980495663 cites W2770377400 @default.
• W2980495663 cites W2770427284 @default.
• W2980495663 doi "https://doi.org/10.1007/s40121-019-00268-3" @default.
• W2980495663 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6856471" @default.
• W2980495663 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31637596" @default.
• W2980495663 hasPublicationYear "2019" @default.
• W2980495663 type Work @default.
• W2980495663 sameAs 2980495663 @default.
• W2980495663 citedByCount "11" @default.
• W2980495663 countsByYear W29804956632020 @default.
• W2980495663 countsByYear W29804956632021 @default.
• W2980495663 countsByYear W29804956632022 @default.
• W2980495663 countsByYear W29804956632023 @default.
• W2980495663 crossrefType "journal-article" @default.
• W2980495663 hasAuthorship W2980495663A5010659587 @default.
• W2980495663 hasAuthorship W2980495663A5012893972 @default.
• W2980495663 hasAuthorship W2980495663A5052246119 @default.
• W2980495663 hasAuthorship W2980495663A5067362047 @default.
• W2980495663 hasAuthorship W2980495663A5070110549 @default.
• W2980495663 hasAuthorship W2980495663A5077074926 @default.
• W2980495663 hasAuthorship W2980495663A5083261865 @default.
• W2980495663 hasAuthorship W2980495663A5084829703 @default.
• W2980495663 hasBestOaLocation W29804956631 @default.
• W2980495663 hasConcept C120665830 @default.
• W2980495663 hasConcept C121332964 @default.
• W2980495663 hasConcept C126189478 @default.
• W2980495663 hasConcept C126322002 @default.
• W2980495663 hasConcept C141071460 @default.
• W2980495663 hasConcept C167135981 @default.
• W2980495663 hasConcept C2778980435 @default.
• W2980495663 hasConcept C2779443120 @default.
• W2980495663 hasConcept C2779489039 @default.
• W2980495663 hasConcept C29730261 @default.
• W2980495663 hasConcept C35294091 @default.
• W2980495663 hasConcept C501593827 @default.
• W2980495663 hasConcept C523546767 @default.
• W2980495663 hasConcept C54355233 @default.
• W2980495663 hasConcept C61511704 @default.
• W2980495663 hasConcept C71924100 @default.
• W2980495663 hasConcept C86803240 @default.
• W2980495663 hasConcept C89423630 @default.
• W2980495663 hasConceptScore W2980495663C120665830 @default.
• W2980495663 hasConceptScore W2980495663C121332964 @default.
• W2980495663 hasConceptScore W2980495663C126189478 @default.
• W2980495663 hasConceptScore W2980495663C126322002 @default.
• W2980495663 hasConceptScore W2980495663C141071460 @default.
• W2980495663 hasConceptScore W2980495663C167135981 @default.
• W2980495663 hasConceptScore W2980495663C2778980435 @default.
• W2980495663 hasConceptScore W2980495663C2779443120 @default.
• W2980495663 hasConceptScore W2980495663C2779489039 @default.
• W2980495663 hasConceptScore W2980495663C29730261 @default.
• W2980495663 hasConceptScore W2980495663C35294091 @default.
• W2980495663 hasConceptScore W2980495663C501593827 @default.
• W2980495663 hasConceptScore W2980495663C523546767 @default.
• W2980495663 hasConceptScore W2980495663C54355233 @default.
• W2980495663 hasConceptScore W2980495663C61511704 @default.
• W2980495663 hasConceptScore W2980495663C71924100 @default.
• W2980495663 hasConceptScore W2980495663C86803240 @default.
• W2980495663 hasConceptScore W2980495663C89423630 @default.
• W2980495663 hasIssue "4" @default.

• next