Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980495791> ?p ?o ?g. }
- W2980495791 endingPage "61" @default.
- W2980495791 startingPage "48" @default.
- W2980495791 abstract "Pulmonary delivery of active drugs has been applied for the treatment of obstructive lung diseases, including asthma, chronic obstructive pulmonary disease and cystic fibrosis, for several decades and has achieved progress in symptom management by bronchodilator inhalation. However, substantial progress in anti-inflammation, prevention of airway remodeling and disease progression is limited, since the majority of the formulation strategies focus only on particle deposition, which is insufficient for pulmonary delivery of the drugs. The lack of knowledge on lung absorption barriers in obstructive lung diseases and on pathogenesis impedes the development of functional formulations by rational design. In this review, we describe the physiological structure and biological functions of the barriers in various regions of the lung, review the pathogenesis and functional changes of barriers in obstructive lung diseases, and examine the interaction of these barriers with particles to influence drug delivery efficiency. Subsequently, we review rational particle design for overcoming lung barriers based on excipients selection, particle size and surface properties, release properties and targeting ability. Additionally, useful particle fabrication strategies and commonly used drug carriers for pulmonary delivery in obstructive lung diseases are proposed in this article." @default.
- W2980495791 created "2019-10-25" @default.
- W2980495791 creator A5014965525 @default.
- W2980495791 creator A5050425416 @default.
- W2980495791 creator A5069362421 @default.
- W2980495791 creator A5073924376 @default.
- W2980495791 creator A5078432389 @default.
- W2980495791 creator A5091519094 @default.
- W2980495791 date "2019-11-01" @default.
- W2980495791 modified "2023-10-17" @default.
- W2980495791 title "Rational particle design to overcome pulmonary barriers for obstructive lung diseases therapy" @default.
- W2980495791 cites W111579719 @default.
- W2980495791 cites W1530405706 @default.
- W2980495791 cites W1600060132 @default.
- W2980495791 cites W1693638809 @default.
- W2980495791 cites W1875971391 @default.
- W2980495791 cites W1940085777 @default.
- W2980495791 cites W1967115789 @default.
- W2980495791 cites W1975132504 @default.
- W2980495791 cites W1975572445 @default.
- W2980495791 cites W1977197389 @default.
- W2980495791 cites W1978811535 @default.
- W2980495791 cites W1979728865 @default.
- W2980495791 cites W1980803266 @default.
- W2980495791 cites W1981812874 @default.
- W2980495791 cites W1983007728 @default.
- W2980495791 cites W1988082304 @default.
- W2980495791 cites W1988327627 @default.
- W2980495791 cites W1989966522 @default.
- W2980495791 cites W1990470477 @default.
- W2980495791 cites W1990471025 @default.
- W2980495791 cites W1990644947 @default.
- W2980495791 cites W1995167963 @default.
- W2980495791 cites W1998100955 @default.
- W2980495791 cites W1998867182 @default.
- W2980495791 cites W2000228858 @default.
- W2980495791 cites W2009508594 @default.
- W2980495791 cites W2011722420 @default.
- W2980495791 cites W2013244153 @default.
- W2980495791 cites W2015351866 @default.
- W2980495791 cites W2016745368 @default.
- W2980495791 cites W2019364338 @default.
- W2980495791 cites W2025134962 @default.
- W2980495791 cites W2025351758 @default.
- W2980495791 cites W2028210174 @default.
- W2980495791 cites W2028336551 @default.
- W2980495791 cites W2030394440 @default.
- W2980495791 cites W2031898059 @default.
- W2980495791 cites W2034000631 @default.
- W2980495791 cites W2040017474 @default.
- W2980495791 cites W2042583859 @default.
- W2980495791 cites W2048971450 @default.
- W2980495791 cites W2049281680 @default.
- W2980495791 cites W2053798956 @default.
- W2980495791 cites W2057313485 @default.
- W2980495791 cites W2058030003 @default.
- W2980495791 cites W2062342035 @default.
- W2980495791 cites W2064966602 @default.
- W2980495791 cites W2065360137 @default.
- W2980495791 cites W2065904350 @default.
- W2980495791 cites W2068628796 @default.
- W2980495791 cites W2068917179 @default.
- W2980495791 cites W2070580570 @default.
- W2980495791 cites W2072373568 @default.
- W2980495791 cites W2074467065 @default.
- W2980495791 cites W2077197422 @default.
- W2980495791 cites W2077722212 @default.
- W2980495791 cites W2079260788 @default.
- W2980495791 cites W2085051997 @default.
- W2980495791 cites W2089890078 @default.
- W2980495791 cites W2090296464 @default.
- W2980495791 cites W2092067512 @default.
- W2980495791 cites W2094909538 @default.
- W2980495791 cites W2095549754 @default.
- W2980495791 cites W2118957675 @default.
- W2980495791 cites W2120579640 @default.
- W2980495791 cites W2125445020 @default.
- W2980495791 cites W2125532863 @default.
- W2980495791 cites W2125851698 @default.
- W2980495791 cites W2127654256 @default.
- W2980495791 cites W2132848564 @default.
- W2980495791 cites W2136199835 @default.
- W2980495791 cites W2138099852 @default.
- W2980495791 cites W2138394603 @default.
- W2980495791 cites W2138914111 @default.
- W2980495791 cites W2143584019 @default.
- W2980495791 cites W2143982567 @default.
- W2980495791 cites W2151568144 @default.
- W2980495791 cites W2155071789 @default.
- W2980495791 cites W2163371839 @default.
- W2980495791 cites W2165098074 @default.
- W2980495791 cites W2169862673 @default.
- W2980495791 cites W2171099227 @default.
- W2980495791 cites W2235198151 @default.
- W2980495791 cites W2288456615 @default.
- W2980495791 cites W2297794140 @default.
- W2980495791 cites W2300291636 @default.
- W2980495791 cites W2397508962 @default.