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• W2980498068 abstract "Alzheimer's disease (AD) is marked by the accumulation of Amyloid beta peptides, neuronal cell death, and synapse loss. However, dysregulation of voltage gated ion channels may also contribute to AD progression. Our lab has shown that in the dorsal hippocampus of transgenic mouse models of AD, CA1 pyramidal neurons exhibit a channelopathy in which hyperpolarization-activated cyclic-nucleotide gated (HCN) channels are mislocalized. However, magnetic resonance imaging (MRI) studies have shown that the anterior hippocampus, corresponding to the ventral hippocampus of rodents, atrophies at a faster rate than the posterior. Additionally, the ventral hippocampus in AD mouse models appears to have more aggressive plaque pathology than the dorsal portion. Therefore, it is important to investigate the possibility that the HCN channelopathy observed in the dorsal hippocampus is also present in the ventral hippocampus. Both 3xTg and 5xFAD mouse models were used. Immunogold electron microscopy was used to assess the relative quantity and location of HCN channels within neurons. And whole cell patch clamp was used to measure accommodation, sag, and rebound slope. Similar to the dorsal hippocampus, the ventral hippocampus exhibits altered physiology that suggests mixed HCN channelopathy. There was little to no evidence of exacerbated accommodation in the ventral hippocampus. However the transgenic mouse neurons showed both gain and loss of function indicated by altered sags and rebound slopes. Preliminary experiments indicate that ventral HCN channels are mislocalized similarly to dorsal channels in transgenic mouse models of AD. Besides the lack of exacerbated accommodation, the ventral and dorsal hippocampi exhibit similar patterns of channelopathy. Additionally, it appears likely that the measurably altered physiology from the wild type mice is due to mislocalization of HCN channel proteins." @default.
• W2980498068 created "2019-10-25" @default.
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• W2980498068 date "2019-07-01" @default.
• W2980498068 modified "2023-09-28" @default.
• W2980498068 title "P3-170: HCN CHANNELOPATHY IN THE VENTRAL HIPPOCAMPUS OF ALZHEIMER'S DISEASE MOUSE MODELS" @default.
• W2980498068 doi "https://doi.org/10.1016/j.jalz.2019.06.3199" @default.
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