FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980498629> ?p ?o ?g. }

• W2980498629 endingPage "4920" @default.
• W2980498629 startingPage "4920" @default.
• W2980498629 abstract "Abstract Aim Pregnancy outcomes in women with Sickle Cell Disease (SCD) have traditionally been poor with rates of both maternal and fetal complications greater than that seen in non-SCD populations (Oteng-Ntim et al, 2015). This association has been demonstrated across both low- and high-income countries with no significant correlation to discrepancies in health care (Boafor et al, 2015). Complications associated with pregnancy in SCD include preterm delivery, intrauterine growth restriction (IUGR), low birth weight, fetal distress in labour, Cesarean section, eclampsia, sickle cell vaso-occlusive crisis, infection, postpartum hemorrhage, and perinatal and maternal death. The introduction of prophylactic Red Cell Exchange (RCE) for high-risk SCD patients has seen a significant reduction in SCD-associated morbidity and mortality (Josephson et al, 2007). Limited studies have examined whether prophylactic RCE also translates to improved pregnancy outcomes in the SCD population with mixed conclusions (Asma et al, 2015). Whilst the association between SCD and adverse pregnancy outcomes has been well characterised in large multi-centre retrospective studies internationally, local data of pregnancy outcomes in SCD, particularly in patients receiving regular RCE, is lacking. Method We conducted a retrospective review of pregnancies within the SCD population managed at the Royal Melbourne Hospital between 2001 (date of commencement of regular RCE program) and 2018 to identify pregnancy complications and outcomes. Medical records across two sites (the Royal Melbourne Hospital and the Royal Women's Hospital) were reviewed to identify patient demographics, RCE received, mode and date of delivery, birth weight, fetal and maternal complications, and outcome of pregnancy. Results We identified 10 pregnancies amongst 5 patients with SCD managed during this time. Three patients had HbSS and two HbSC disease. Mean maternal age at time of pregnancy was 27 years. Two patients were receiving regular RCE prior to pregnancy and continued throughout at 3 to 4 week intervals, with a further patient commenced on RCE at 27/40 as per local hospital practice. Of the 3 women receiving regular RCE during pregnancy, all had live births (n=7); 1 via normal vaginal delivery (NVD) and 6 elective Cesarean-section due to cephalopelvic disproportion. Six of these pregnancies were at term, with one induced at 32/40 due to line sepsis as a complication of RCE. Two pregnancies were also complicated by gestational diabetes. Two patients were not managed with regular RCE. The first declined treatment throughout both pregnancies, with pregnancy 1 complicated by intrauterine growth restriction (IUGR) with delivery via NVD at 37/40, and pregnancy 2 complicated by placental abruption and fetal death in utero (FDIU) at 22/40. Both pregnancies were also complicated by gestational thrombocytopenia. The second patient was on hydroxyurea (HU) at time of conception, initially continued during pregnancy in the setting of normal morphology scans and a rare blood phenotype prohibitive of RCE. HU was subsequently ceased at 27/40 due to the development of IUGR. She was commenced on RCE at 30/40 but suffered placental abruption and FDIU at 34/40. No offspring had a haemoglobinopathy of clinical significance. Conclusion RCE was well-tolerated and associated with good and possibly improved maternal and fetal outcomes in this small cohort of sickle cell patients. Larger studies are required to further characterise the benefit of prophylactic RCE during pregnancy in the SCD population. Disclosures Szer: Alexion Pharmaceuticals, Inc.: Consultancy, Honoraria, Other: Travel Support , Research Funding." @default.
• W2980498629 created "2019-10-25" @default.
• W2980498629 creator A5010288623 @default.
• W2980498629 creator A5031643718 @default.
• W2980498629 creator A5042172627 @default.
• W2980498629 creator A5042210977 @default.
• W2980498629 creator A5056324649 @default.
• W2980498629 date "2018-11-29" @default.
• W2980498629 modified "2023-10-01" @default.
• W2980498629 title "A Local Experience of Pregnancy Outcomes in Sickle Cell Disease and Red Cell Exchange" @default.
• W2980498629 doi "https://doi.org/10.1182/blood-2018-99-116191" @default.
• W2980498629 hasPublicationYear "2018" @default.
• W2980498629 type Work @default.
• W2980498629 sameAs 2980498629 @default.
• W2980498629 citedByCount "0" @default.
• W2980498629 crossrefType "journal-article" @default.
• W2980498629 hasAuthorship W2980498629A5010288623 @default.
• W2980498629 hasAuthorship W2980498629A5031643718 @default.
• W2980498629 hasAuthorship W2980498629A5042172627 @default.
• W2980498629 hasAuthorship W2980498629A5042210977 @default.
• W2980498629 hasAuthorship W2980498629A5056324649 @default.
• W2980498629 hasBestOaLocation W29804986291 @default.
• W2980498629 hasConcept C131872663 @default.
• W2980498629 hasConcept C141071460 @default.
• W2980498629 hasConcept C167135981 @default.
• W2980498629 hasConcept C172680121 @default.
• W2980498629 hasConcept C187212893 @default.
• W2980498629 hasConcept C195910791 @default.
• W2980498629 hasConcept C2777218350 @default.
• W2980498629 hasConcept C2778780700 @default.
• W2980498629 hasConcept C2779083892 @default.
• W2980498629 hasConcept C2779234561 @default.
• W2980498629 hasConcept C2780109559 @default.
• W2980498629 hasConcept C2908647359 @default.
• W2980498629 hasConcept C54355233 @default.
• W2980498629 hasConcept C71924100 @default.
• W2980498629 hasConcept C86803240 @default.
• W2980498629 hasConcept C99454951 @default.
• W2980498629 hasConceptScore W2980498629C131872663 @default.
• W2980498629 hasConceptScore W2980498629C141071460 @default.
• W2980498629 hasConceptScore W2980498629C167135981 @default.
• W2980498629 hasConceptScore W2980498629C172680121 @default.
• W2980498629 hasConceptScore W2980498629C187212893 @default.
• W2980498629 hasConceptScore W2980498629C195910791 @default.
• W2980498629 hasConceptScore W2980498629C2777218350 @default.
• W2980498629 hasConceptScore W2980498629C2778780700 @default.
• W2980498629 hasConceptScore W2980498629C2779083892 @default.
• W2980498629 hasConceptScore W2980498629C2779234561 @default.
• W2980498629 hasConceptScore W2980498629C2780109559 @default.
• W2980498629 hasConceptScore W2980498629C2908647359 @default.
• W2980498629 hasConceptScore W2980498629C54355233 @default.
• W2980498629 hasConceptScore W2980498629C71924100 @default.
• W2980498629 hasConceptScore W2980498629C86803240 @default.
• W2980498629 hasConceptScore W2980498629C99454951 @default.
• W2980498629 hasIssue "Supplement 1" @default.
• W2980498629 hasLocation W29804986291 @default.
• W2980498629 hasOpenAccess W2980498629 @default.
• W2980498629 hasPrimaryLocation W29804986291 @default.
• W2980498629 hasRelatedWork W1980283574 @default.
• W2980498629 hasRelatedWork W2084964913 @default.
• W2980498629 hasRelatedWork W2330010889 @default.
• W2980498629 hasRelatedWork W2368136628 @default.
• W2980498629 hasRelatedWork W3004853179 @default.
• W2980498629 hasRelatedWork W3105631608 @default.
• W2980498629 hasRelatedWork W3125589036 @default.
• W2980498629 hasRelatedWork W3217012476 @default.
• W2980498629 hasRelatedWork W4247607612 @default.
• W2980498629 hasRelatedWork W2487306397 @default.
• W2980498629 hasVolume "132" @default.
• W2980498629 isParatext "false" @default.
• W2980498629 isRetracted "false" @default.
• W2980498629 magId "2980498629" @default.
• W2980498629 workType "article" @default.