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- W2980520891 abstract "Multiple myeloma (MM) is a plasma cell malignancy, that currently remains incurable. The identification of CD38, a transmembrane glycoprotein overexpressed on MM cells, led to the development of target-specific therapeutics such as the FDA-approved monoclonal antibody (mAb) Daratumumab. Although a valuable treatment option for refractory/relapsed MM patients, Daratumumab has a limiting response rate of about 30%, which highlights the clinical need for novel therapeutics. A modern alternative to antibody-based technologies is the genetic modification of effector cells into expressing highly-selective chimeric antigen receptors (CARs)." @default.
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- W2980520891 date "2019-10-01" @default.
- W2980520891 modified "2023-10-02" @default.
- W2980520891 title "A novel antiCD38-CAR construct increases the in vitro responsiveness of NK cells against Multiple Myeloma cells" @default.
- W2980520891 doi "https://doi.org/10.1016/j.clml.2019.09.273" @default.
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