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- W2980521834 endingPage "809" @default.
- W2980521834 startingPage "809" @default.
- W2980521834 abstract "Copy number variation (CNV) has great significance both functionally and evolutionally. Various CNV studies are in progress to find the cause of human disease and to understand the population structure of livestock. Recent advances in next-generation sequencing (NGS) technology have made CNV detection more reliable and accurate at whole-genome level. However, there is a lack of CNV studies on chickens using NGS. Therefore, we obtained whole-genome sequencing data of 65 chickens including Red Jungle Fowl, Cornish (broiler), Rhode Island Red (hybrid), and White Leghorn (layer) from the public databases for CNV region (CNVR) detection. Using CNVnator, a read-depth based software, a total of 663 domesticated-specific CNVRs were identified across autosomes. Gene ontology analysis of genes annotated in CNVRs showed that mainly enriched terms involved in organ development, metabolism, and immune regulation. Population analysis revealed that CN and RIR are closer to each other than WL, and many genes (LOC772271, OR52R1, RD3, ADH6, TLR2B, PRSS2, TPK1, POPDC3, etc.) with different copy numbers between breeds found. In conclusion, this study has helped to understand the genetic characteristics of domestic chickens at CNV level, which may provide useful information for the development of breeding systems in chickens." @default.
- W2980521834 created "2019-10-25" @default.
- W2980521834 creator A5021858665 @default.
- W2980521834 creator A5026175338 @default.
- W2980521834 creator A5034746659 @default.
- W2980521834 creator A5066209020 @default.
- W2980521834 creator A5081590055 @default.
- W2980521834 creator A5083035763 @default.
- W2980521834 date "2019-10-15" @default.
- W2980521834 modified "2023-10-01" @default.
- W2980521834 title "Identification of Copy Number Variation in Domestic Chicken Using Whole-Genome Sequencing Reveals Evidence of Selection in the Genome" @default.
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