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• W2980542012 abstract "Introduction Over the last decades researchers discuss the interconnection between obesity and metabolic syndrome, the main manifestations of which include obesity, dyslipidemia, insulin resistance, and hypertension. Aim To determine biochemical parameters in obese adolescents of Asian and Caucasian ethnicities, living in a rural area. Materials and methods We investigated 200 adolescents with overweight and obesity aged 11–17 years: 43 Asian adolescents and 29 Caucasian adolescents. The control group comprised 128 adolescents with normal body weight in both ethnic groups. All adolescents were living in Buryatia (Russia). Overweight was diagnosed when body mass index (BMI)>85 percentile, obesity – at BMI ≥ 95. Metabolic status was established by the spectrophotometric method. The following parameters were determined and analyzed: total cholesterol, high and low density lipoproteins fractions, triglycerides, fasting glucose and two-hour post-load glucose levels. Results After comparison of biochemical parameters, we found changes in carbohydrate metabolism in obese adolescents. Glucose tolerance test showed significant differences between two-hour post-load glucose levels between groups with obesity and normal body weight (4.63 ± 0.62 mmol/L against 3.89 ± 0.62 mmol/L, respectively in Asian adolescents, p = 0.000 и 4.48 ± 0.9 mmol/L against 3.89 ± 0.5 mmol/L, respectively in Caucasian adolescents, p = 0.000). We found significant differences between levels of this parameter among adolescents with obesity of Asian and Caucasian ethnicities (4.63 ± 0.62 mmol/L against 4.48 ± 0.9 mmol/L, respectively, p = 0.006). Mean group values of fat metabolism in adolescents with obesity were within normal values, however during a frequency analysis we detected changes: hypercholesteremia in 6.8% in Asian adolescents and 4.6% in Caucasian adolescents. Hypertriglyceridemia was detected in 16.3% cases of Asians and 9.2% in the Caucasian group, p=0.007. Hypolipoproteinemia in obese adolescents was noticed in 6.7% of Asians (in Caucasian group –3.4%, p = 0.569). Conclusions Therefore all metabolic changes, mentioned above, are more typical for the natives than for newcomer, namely, Caucasian people, which probably may be associated with food stereotypes and consuming food rich in animal fats. At the same time traditional food stereotypes in Asian ethnicities may contribute to adaptation to atherogenesis and development of resistance to atherosclerosis and diabetes mellitus, predominantly of the type 1." @default.
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• W2980542012 date "2019-06-01" @default.
• W2980542012 modified "2023-09-27" @default.
• W2980542012 title "P517 Metabolic features of adolescents with obesity" @default.
• W2980542012 doi "https://doi.org/10.1136/archdischild-2019-epa.852" @default.
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