FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980547029> ?p ?o ?g. }

• W2980547029 endingPage "A878" @default.
• W2980547029 startingPage "A878" @default.
• W2980547029 abstract "SESSION TITLE: Pulmonary Manifestations of Systemic Disease SESSION TYPE: Med Student/Res Case Report PRESENTED ON: 10/23/2019 8:45 AM - 9:45 AM INTRODUCTION: POEMS is a rare syndrome thought to be due to underlying plasma cell neoplasia. Diagnosis is by clinical syndrome with major and minor criteria that include polyradiculoneuropathy, clonal plasma cell disorder, sclerotic bone lesions, organomegaly, extravascular volume overload, endocrinopathy, and hematologic changes.1 Presented below is a case of POEMS presenting as volume overload and hypoxia originally misclassified as heart failure. CASE PRESENTATION: A 78-year-old woman presented to the hospital with 2 weeks of worsening shortness of breath and fatigue in the setting of 8 months of progressing leg and belly swelling. She had a history of type 2 diabetes, hypertension, neuropathy, and monoclonal gammopathy. She originally presented to her PCP 8 months prior for the leg swelling. After basic work up she was diagnosed with heart failure and started on diuretics, but despite increasing doses her volume overload progressed. She developed significant shortness of breath and presented to an outside hospital where she was treated with diuretics and discharged to a rehab facility. When the fluid quickly came back and she became short of breath she presented to our hospital.On admission she was anasarcic and in respiratory distress with hypoxia requiring 2 liters oxygen. Chest x ray showed bilateral pleural effusions. She was diagnosed with a heart failure exacerbation and started on IV diuretics. Given her effusions and hypoxia pulmonary was consulted for thoracentesis.Several components of her work up were atypical. Further history revealed her neuropathy preceded diabetes by 10 years. Her admission labs showed anemia, elevated monocytes, and subclinical hypothyroidism. Her echo showed a moderate pericardial effusion and only mild diastolic dysfunction. POEMS was suspected as a possible cause.Her work up was broadened and revealed a kappa gammaglobulinemia. Thoracentesis showed an exudative effusion without malignant cells. Chest CT showed residual effusions and dependent atelectasis without other abnormalities. Flow cytometry confirmed MGUS, and bone marrow biopsy was normal. VEGF level was 93. Skeletal survey showed a sclerotic lesion of the ileum. Other work up for infection, amyloid, and malignancy were negative. DISCUSSION: Our patient was diagnosed with POEMS and continued on supportive care. She had PFTs showing restrictive lung disease, and right heart cath was normal. She was discharged with pulmonary and oncology follow up. CONCLUSIONS: POEMS is a rare syndrome thought secondary to plasma cell neoplasia with multiple organ involvement. Common pulmonary manifestations are pleural effusions, pulmonary hypertension, and restrictive lung disease. Our patient presented with effusions and hypoxia originally misdiagnosed as heart failure. Careful history and recognition of abnormalities on routine blood work led to the appropriate work up and diagnosis. Reference #1: 1. Dispenzieri A. POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management. Am J Hematol. 2017. https://doi.org/10.1002/ajh.24802 DISCLOSURES: No relevant relationships by Daniel Guidot, source=Web Response" @default.
• W2980547029 created "2019-10-25" @default.
• W2980547029 creator A5016193706 @default.
• W2980547029 date "2019-10-01" @default.
• W2980547029 modified "2023-09-25" @default.
• W2980547029 title "POEMS SYNDROME PRESENTING AS HYPOXIC RESPIRATORY FAILURE WITH PLEURAL EFFUSIONS" @default.
• W2980547029 doi "https://doi.org/10.1016/j.chest.2019.08.829" @default.
• W2980547029 hasPublicationYear "2019" @default.
• W2980547029 type Work @default.
• W2980547029 sameAs 2980547029 @default.
• W2980547029 citedByCount "0" @default.
• W2980547029 crossrefType "journal-article" @default.
• W2980547029 hasAuthorship W2980547029A5016193706 @default.
• W2980547029 hasConcept C126322002 @default.
• W2980547029 hasConcept C141071460 @default.
• W2980547029 hasConcept C141983124 @default.
• W2980547029 hasConcept C24595384 @default.
• W2980547029 hasConcept C2775892965 @default.
• W2980547029 hasConcept C2776210965 @default.
• W2980547029 hasConcept C2776212140 @default.
• W2980547029 hasConcept C2776888751 @default.
• W2980547029 hasConcept C2778198053 @default.
• W2980547029 hasConcept C2778551932 @default.
• W2980547029 hasConcept C2779634585 @default.
• W2980547029 hasConcept C2780930700 @default.
• W2980547029 hasConcept C71924100 @default.
• W2980547029 hasConceptScore W2980547029C126322002 @default.
• W2980547029 hasConceptScore W2980547029C141071460 @default.
• W2980547029 hasConceptScore W2980547029C141983124 @default.
• W2980547029 hasConceptScore W2980547029C24595384 @default.
• W2980547029 hasConceptScore W2980547029C2775892965 @default.
• W2980547029 hasConceptScore W2980547029C2776210965 @default.
• W2980547029 hasConceptScore W2980547029C2776212140 @default.
• W2980547029 hasConceptScore W2980547029C2776888751 @default.
• W2980547029 hasConceptScore W2980547029C2778198053 @default.
• W2980547029 hasConceptScore W2980547029C2778551932 @default.
• W2980547029 hasConceptScore W2980547029C2779634585 @default.
• W2980547029 hasConceptScore W2980547029C2780930700 @default.
• W2980547029 hasConceptScore W2980547029C71924100 @default.
• W2980547029 hasIssue "4" @default.
• W2980547029 hasLocation W29805470291 @default.
• W2980547029 hasOpenAccess W2980547029 @default.
• W2980547029 hasPrimaryLocation W29805470291 @default.
• W2980547029 hasRelatedWork W1834852860 @default.
• W2980547029 hasRelatedWork W1976090658 @default.
• W2980547029 hasRelatedWork W2060507304 @default.
• W2980547029 hasRelatedWork W2089656606 @default.
• W2980547029 hasRelatedWork W2168630507 @default.
• W2980547029 hasRelatedWork W2354773237 @default.
• W2980547029 hasRelatedWork W2376351185 @default.
• W2980547029 hasRelatedWork W2750508533 @default.
• W2980547029 hasRelatedWork W4302444387 @default.
• W2980547029 hasRelatedWork W46233310 @default.
• W2980547029 hasVolume "156" @default.
• W2980547029 isParatext "false" @default.
• W2980547029 isRetracted "false" @default.
• W2980547029 magId "2980547029" @default.
• W2980547029 workType "article" @default.