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- W2980549036 abstract "T cell specification and commitment require Notch signaling. Although the requirement for Notch signaling during intrathymic T cell development is known, it is still unclear whether the onset of T cell priming can occur in a prethymic niche and whether RBPJ-dependent Notch signaling has a role during this event. Here, we established an Rbpj-inducible system that allowed temporal and tissue-specific control of the responsiveness to Notch in all hematopoietic cells. Using this system, we found that Notch signaling was required before the early T cell progenitor stage in the thymus. Lymphoid-primed multipotent progenitors in the bone marrow underwent Notch signaling with Rbpj induction, which inhibited development towards the myeloid lineage in thymus-seeding progenitors. Thus, our results indicated that the onset of T cell differentiation occurred in a prethymic setting, and that Notch played an important role during this event. Zúñiga-Pflücker and colleagues show that Notch signaling is required before the thymic stages of T cell development to inhibit the myeloid lineage potential in thymus-seeding progenitors." @default.
- W2980549036 created "2019-10-25" @default.
- W2980549036 creator A5024973377 @default.
- W2980549036 creator A5044412037 @default.
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- W2980549036 date "2019-10-21" @default.
- W2980549036 modified "2023-10-12" @default.
- W2980549036 title "RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors" @default.
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- W2980549036 doi "https://doi.org/10.1038/s41590-019-0518-7" @default.
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