Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980558323> ?p ?o ?g. }
- W2980558323 abstract "Abstract The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts." @default.
- W2980558323 created "2019-10-25" @default.
- W2980558323 creator A5000250919 @default.
- W2980558323 creator A5001132124 @default.
- W2980558323 creator A5001640598 @default.
- W2980558323 creator A5001739428 @default.
- W2980558323 creator A5001881311 @default.
- W2980558323 creator A5001909300 @default.
- W2980558323 creator A5002742583 @default.
- W2980558323 creator A5002824850 @default.
- W2980558323 creator A5003929789 @default.
- W2980558323 creator A5004386906 @default.
- W2980558323 creator A5004621969 @default.
- W2980558323 creator A5004895861 @default.
- W2980558323 creator A5005156493 @default.
- W2980558323 creator A5005279462 @default.
- W2980558323 creator A5005786454 @default.
- W2980558323 creator A5006499595 @default.
- W2980558323 creator A5006680848 @default.
- W2980558323 creator A5006967177 @default.
- W2980558323 creator A5007390241 @default.
- W2980558323 creator A5007639526 @default.
- W2980558323 creator A5007656583 @default.
- W2980558323 creator A5008006023 @default.
- W2980558323 creator A5008573099 @default.
- W2980558323 creator A5008664061 @default.
- W2980558323 creator A5008841181 @default.
- W2980558323 creator A5010083385 @default.
- W2980558323 creator A5010428487 @default.
- W2980558323 creator A5011150274 @default.
- W2980558323 creator A5011722240 @default.
- W2980558323 creator A5011886992 @default.
- W2980558323 creator A5012112885 @default.
- W2980558323 creator A5012235494 @default.
- W2980558323 creator A5013128015 @default.
- W2980558323 creator A5013309714 @default.
- W2980558323 creator A5013347012 @default.
- W2980558323 creator A5013682639 @default.
- W2980558323 creator A5013928770 @default.
- W2980558323 creator A5014208337 @default.
- W2980558323 creator A5014235743 @default.
- W2980558323 creator A5014284483 @default.
- W2980558323 creator A5014942240 @default.
- W2980558323 creator A5015482136 @default.
- W2980558323 creator A5016254885 @default.
- W2980558323 creator A5016359506 @default.
- W2980558323 creator A5016753010 @default.
- W2980558323 creator A5017006608 @default.
- W2980558323 creator A5017643089 @default.
- W2980558323 creator A5017787850 @default.
- W2980558323 creator A5017836498 @default.
- W2980558323 creator A5018600726 @default.
- W2980558323 creator A5019614984 @default.
- W2980558323 creator A5019839364 @default.
- W2980558323 creator A5020145495 @default.
- W2980558323 creator A5020362713 @default.
- W2980558323 creator A5021628160 @default.
- W2980558323 creator A5021879937 @default.
- W2980558323 creator A5022733294 @default.
- W2980558323 creator A5022895698 @default.
- W2980558323 creator A5022930642 @default.
- W2980558323 creator A5024385551 @default.
- W2980558323 creator A5024635734 @default.
- W2980558323 creator A5025639170 @default.
- W2980558323 creator A5025837351 @default.
- W2980558323 creator A5026153073 @default.
- W2980558323 creator A5026404982 @default.
- W2980558323 creator A5026837875 @default.
- W2980558323 creator A5027973785 @default.
- W2980558323 creator A5027984154 @default.
- W2980558323 creator A5027997496 @default.
- W2980558323 creator A5028735854 @default.
- W2980558323 creator A5028916691 @default.
- W2980558323 creator A5029238451 @default.
- W2980558323 creator A5029811295 @default.
- W2980558323 creator A5030581253 @default.
- W2980558323 creator A5031066739 @default.
- W2980558323 creator A5031467310 @default.
- W2980558323 creator A5032156230 @default.
- W2980558323 creator A5032637491 @default.
- W2980558323 creator A5033247523 @default.
- W2980558323 creator A5033949358 @default.
- W2980558323 creator A5034030410 @default.
- W2980558323 creator A5034159112 @default.
- W2980558323 creator A5034309523 @default.
- W2980558323 creator A5035448305 @default.
- W2980558323 creator A5035550715 @default.
- W2980558323 creator A5035863653 @default.
- W2980558323 creator A5036332333 @default.
- W2980558323 creator A5036334348 @default.
- W2980558323 creator A5036534189 @default.
- W2980558323 creator A5036586072 @default.
- W2980558323 creator A5037308493 @default.
- W2980558323 creator A5038424501 @default.
- W2980558323 creator A5038725874 @default.
- W2980558323 creator A5039652584 @default.
- W2980558323 creator A5039736447 @default.
- W2980558323 creator A5040411414 @default.
- W2980558323 creator A5040741583 @default.
- W2980558323 creator A5041783868 @default.