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- W2980585425 abstract "Abstract Pregnenolone (P5) promotes prostate cancer cell growth, and de novo synthesis of intratumoural P5 is a potential cause of development of castration-resistance. Immune cells can also synthesize P5 de novo . Despite its biological importance, little is known about P5’s mode of actions, which appears to be context-dependent and pleiotropic. A comprehensive proteome-wide spectrum of P5-binding proteins that are involved in its trafficking and functionality remains unknown. Here, we describe an approach that integrates chemical biology for probe synthesis with chemoproteomics to map P5-protein interactions in live prostate cancer cells and murine CD8 + T cells. We subsequently identified P5-binding proteins potentially involved in P5-trafficking, and in P5’s non-genomic action that may drive the promotion of castrate-resistance prostate cancer and regulate CD8 + T cell function. We envisage that this methodology could be employed for other steroids to map their interactomes directly in a broad range of living cells, tissues and organisms." @default.
- W2980585425 created "2019-10-25" @default.
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- W2980585425 date "2019-10-16" @default.
- W2980585425 modified "2023-09-26" @default.
- W2980585425 title "CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells" @default.
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- W2980585425 doi "https://doi.org/10.1101/800649" @default.
- W2980585425 hasPublicationYear "2019" @default.
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