FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980594759> ?p ?o ?g. }

• W2980594759 abstract "Resistance to platinum and taxane adjuvant chemotherapy (ACT) is the main cause of the recurrence and poor prognosis of high-grade serous ovarian cancer (HGS-OvCa) patients receiving platinum-taxane ACT after surgery. However, currently reported quantitative transcriptional signatures, which are commonly based on risk scores summarized from gene expression, are unsuitable for clinical application because of their high sensitivity to experimental batch effects and quality uncertainties of clinical samples. Using 226 samples of HGS-OvCa patients receiving platinum-taxane ACT in TCGA, we developed a qualitative transcriptional signature, consisting of four gene pairs whose within-samples relative expression orderings could robustly predict patient recurrence-free survival (RFS). In two independent test datasets, the predicted non-responders had significantly shorter RFS than the predicted responders (log-rank p < 0.05). In a test dataset containing data for patient pathological response state, the signature reclassified 12 out of 22 pathological complete response patients as non-responders and two out of 16 pathological non-complete response patients as responders. Notably, the 12 predicted non-responders in the pathological complete response group had significantly shorter RFS than the predicted responders (log-rank p = 0.0122). This qualitative transcriptional signature, which is insensitive to experimental batch effects and quality uncertainties of clinical samples, can individually identify HGS-OvCa patients who are more likely to benefit from platinum-taxane adjuvant chemotherapy." @default.
• W2980594759 created "2019-10-25" @default.
• W2980594759 creator A5022614909 @default.
• W2980594759 creator A5030202096 @default.
• W2980594759 creator A5032948942 @default.
• W2980594759 creator A5043301109 @default.
• W2980594759 creator A5043417955 @default.
• W2980594759 creator A5060002817 @default.
• W2980594759 creator A5069723993 @default.
• W2980594759 creator A5083495525 @default.
• W2980594759 creator A5087055335 @default.
• W2980594759 creator A5089862145 @default.
• W2980594759 date "2019-10-18" @default.
• W2980594759 modified "2023-10-14" @default.
• W2980594759 title "A Qualitative Transcriptional Signature for Predicting Recurrence Risk for High-Grade Serous Ovarian Cancer Patients Treated With Platinum-Taxane Adjuvant Chemotherapy" @default.
• W2980594759 cites W1820613602 @default.
• W2980594759 cites W1893007615 @default.
• W2980594759 cites W1967706368 @default.
• W2980594759 cites W1970984602 @default.
• W2980594759 cites W2019607817 @default.
• W2980594759 cites W2027787548 @default.
• W2980594759 cites W2035618305 @default.
• W2980594759 cites W2059806955 @default.
• W2980594759 cites W2066427082 @default.
• W2980594759 cites W2079537409 @default.
• W2980594759 cites W2093701073 @default.
• W2980594759 cites W2095264870 @default.
• W2980594759 cites W2113618192 @default.
• W2980594759 cites W2118496272 @default.
• W2980594759 cites W2123696077 @default.
• W2980594759 cites W2129925362 @default.
• W2980594759 cites W2131593373 @default.
• W2980594759 cites W2134175882 @default.
• W2980594759 cites W2134785517 @default.
• W2980594759 cites W2135827569 @default.
• W2980594759 cites W2171658624 @default.
• W2980594759 cites W2256346593 @default.
• W2980594759 cites W2520996698 @default.
• W2980594759 cites W2536264152 @default.
• W2980594759 cites W2555960905 @default.
• W2980594759 cites W2564732085 @default.
• W2980594759 cites W2592746382 @default.
• W2980594759 cites W2600489281 @default.
• W2980594759 cites W2617774329 @default.
• W2980594759 cites W2762379106 @default.
• W2980594759 cites W2770214586 @default.
• W2980594759 cites W2781525129 @default.
• W2980594759 cites W2795309980 @default.
• W2980594759 cites W2869916641 @default.
• W2980594759 cites W2887701952 @default.
• W2980594759 cites W4211203170 @default.
• W2980594759 cites W70984977 @default.
• W2980594759 doi "https://doi.org/10.3389/fonc.2019.01094" @default.
• W2980594759 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6813654" @default.
• W2980594759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31681618" @default.
• W2980594759 hasPublicationYear "2019" @default.
• W2980594759 type Work @default.
• W2980594759 sameAs 2980594759 @default.
• W2980594759 citedByCount "3" @default.
• W2980594759 countsByYear W29805947592022 @default.
• W2980594759 crossrefType "journal-article" @default.
• W2980594759 hasAuthorship W2980594759A5022614909 @default.
• W2980594759 hasAuthorship W2980594759A5030202096 @default.
• W2980594759 hasAuthorship W2980594759A5032948942 @default.
• W2980594759 hasAuthorship W2980594759A5043301109 @default.
• W2980594759 hasAuthorship W2980594759A5043417955 @default.
• W2980594759 hasAuthorship W2980594759A5060002817 @default.
• W2980594759 hasAuthorship W2980594759A5069723993 @default.
• W2980594759 hasAuthorship W2980594759A5083495525 @default.
• W2980594759 hasAuthorship W2980594759A5087055335 @default.
• W2980594759 hasAuthorship W2980594759A5089862145 @default.
• W2980594759 hasBestOaLocation W29805947591 @default.
• W2980594759 hasConcept C121608353 @default.
• W2980594759 hasConcept C126322002 @default.
• W2980594759 hasConcept C143998085 @default.
• W2980594759 hasConcept C207886595 @default.
• W2980594759 hasConcept C2776694085 @default.
• W2980594759 hasConcept C2777292972 @default.
• W2980594759 hasConcept C2777511904 @default.
• W2980594759 hasConcept C2778239845 @default.
• W2980594759 hasConcept C2780427987 @default.
• W2980594759 hasConcept C530470458 @default.
• W2980594759 hasConcept C71924100 @default.
• W2980594759 hasConceptScore W2980594759C121608353 @default.
• W2980594759 hasConceptScore W2980594759C126322002 @default.
• W2980594759 hasConceptScore W2980594759C143998085 @default.
• W2980594759 hasConceptScore W2980594759C207886595 @default.
• W2980594759 hasConceptScore W2980594759C2776694085 @default.
• W2980594759 hasConceptScore W2980594759C2777292972 @default.
• W2980594759 hasConceptScore W2980594759C2777511904 @default.
• W2980594759 hasConceptScore W2980594759C2778239845 @default.
• W2980594759 hasConceptScore W2980594759C2780427987 @default.
• W2980594759 hasConceptScore W2980594759C530470458 @default.
• W2980594759 hasConceptScore W2980594759C71924100 @default.
• W2980594759 hasFunder F4320321001 @default.
• W2980594759 hasFunder F4320323190 @default.
• W2980594759 hasFunder F4320325531 @default.
• W2980594759 hasLocation W29805947591 @default.
• W2980594759 hasLocation W29805947592 @default.
• W2980594759 hasLocation W29805947593 @default.

• next