FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980600196> ?p ?o ?g. }

• W2980600196 abstract "Results from cost-effectiveness (CE) models are sensitive to input parameter values. We compared selected input parameter values in models that estimate the effectiveness of hypothetical disease-modifying treatments (DMTs) for Alzheimer's disease (AD). A targeted literature search of the Medline database from 2010 to present identified disease models for AD that included the impact of hypothetical DMTs. Input parameter values were compared for rate of conversion from mild cognitive impairment (MCI) to dementia, institutionalization and excess mortality rates, utility weights, and costs by disease severity. Eight published models were reviewed: three patient-level simulations, four Markov models, and one using observed MMSE decline rates. Seven models included predementia health states. Annual rates of conversion from MCI to mild AD in the Markov models were similar (∼27%) for populations with biomarker evidence of AD. Conversion rates were lower (∼10%) if all patients with MCI were included in the population. The percentage of patients institutionalized for those with severe AD was 39.3% in two models compared with 76.22% in two other models. A fifth model used annual institutionalization rates of 1.2% for mild dementia, 3.4% for moderate dementia, and 6.6% for severe dementia. Two models assumed no variation in mortality by disease stage. Two other models used an additive factor for mortality for moderate (0.055 or 0.11) and severe (0.11) dementia. In two other models, multiplicative mortality risks were assumed either only for moderate (× 2.52) and severe (× 7.3) dementia or for MCI (× 1.48) and all dementia severities (× 2.84). Finally, differences in utility and costs between MCI and mild AD varied among the models. For example, the decrease in utility between MCI and mild AD was 0.05 in one model and 0.20 in another study. In addition, two models assumed no excess costs for those with MCI, while excess costs derived from observational data were included in two different models. DMTs under development are targeted for those with MCI or mild AD. This review highlights the considerable variability among disease models in transition, institutionalization, excess mortality rates and utility and cost inputs across these two health states." @default.
• W2980600196 created "2019-10-25" @default.
• W2980600196 creator A5014006564 @default.
• W2980600196 creator A5023504826 @default.
• W2980600196 creator A5042419382 @default.
• W2980600196 creator A5067506365 @default.
• W2980600196 date "2019-07-01" @default.
• W2980600196 modified "2023-09-27" @default.
• W2980600196 title "P2-577: THE VARIABILITY IN INPUT PARAMETER VALUES IN MODELS ESTIMATING THE EFFECTIVENESS OF HYPOTHETICAL DISEASE MODIFYING TREATMENTS FOR ALZHEIMER'S DISEASE" @default.
• W2980600196 doi "https://doi.org/10.1016/j.jalz.2019.06.2986" @default.
• W2980600196 hasPublicationYear "2019" @default.
• W2980600196 type Work @default.
• W2980600196 sameAs 2980600196 @default.
• W2980600196 citedByCount "0" @default.
• W2980600196 crossrefType "journal-article" @default.
• W2980600196 hasAuthorship W2980600196A5014006564 @default.
• W2980600196 hasAuthorship W2980600196A5023504826 @default.
• W2980600196 hasAuthorship W2980600196A5042419382 @default.
• W2980600196 hasAuthorship W2980600196A5067506365 @default.
• W2980600196 hasBestOaLocation W29806001961 @default.
• W2980600196 hasConcept C126322002 @default.
• W2980600196 hasConcept C144024400 @default.
• W2980600196 hasConcept C149923435 @default.
• W2980600196 hasConcept C2779134260 @default.
• W2980600196 hasConcept C2779483572 @default.
• W2980600196 hasConcept C2908647359 @default.
• W2980600196 hasConcept C71924100 @default.
• W2980600196 hasConcept C74909509 @default.
• W2980600196 hasConcept C99454951 @default.
• W2980600196 hasConceptScore W2980600196C126322002 @default.
• W2980600196 hasConceptScore W2980600196C144024400 @default.
• W2980600196 hasConceptScore W2980600196C149923435 @default.
• W2980600196 hasConceptScore W2980600196C2779134260 @default.
• W2980600196 hasConceptScore W2980600196C2779483572 @default.
• W2980600196 hasConceptScore W2980600196C2908647359 @default.
• W2980600196 hasConceptScore W2980600196C71924100 @default.
• W2980600196 hasConceptScore W2980600196C74909509 @default.
• W2980600196 hasConceptScore W2980600196C99454951 @default.
• W2980600196 hasIssue "7S_Part_16" @default.
• W2980600196 hasLocation W29806001961 @default.
• W2980600196 hasOpenAccess W2980600196 @default.
• W2980600196 hasPrimaryLocation W29806001961 @default.
• W2980600196 hasRelatedWork W1501867320 @default.
• W2980600196 hasRelatedWork W2059242980 @default.
• W2980600196 hasRelatedWork W2413479035 @default.
• W2980600196 hasRelatedWork W2990530825 @default.
• W2980600196 hasRelatedWork W313460363 @default.
• W2980600196 hasRelatedWork W4235339219 @default.
• W2980600196 hasRelatedWork W4236243970 @default.
• W2980600196 hasRelatedWork W4249661632 @default.
• W2980600196 hasRelatedWork W4255249625 @default.
• W2980600196 hasRelatedWork W2941673797 @default.
• W2980600196 hasVolume "15" @default.
• W2980600196 isParatext "false" @default.
• W2980600196 isRetracted "false" @default.
• W2980600196 magId "2980600196" @default.
• W2980600196 workType "article" @default.