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- W2980618300 abstract "While being obesity in mid-life is associated with an increased risk of dementia and cognitive decline in late-life, being obesity in late-life is conversely associated with a lower risk of these outcomes. This phenomenon is known as the “obesity paradox”, usually observed using BMI. However, the underlying reasons and possible sex difference in the association are yet to be examined in late-life. We investigated the associations between domain-specific cognitive function and waist circumference (WC), an alternative measure of abdominal fatness which can be measured easier than BMI among older adults in each generation of late-life. Participants were randomly sampled from residents aged 65-74, 75–84 and 85+ years in Takashima County, Shiga Prefecture, Japan during 2005-2006. Associations between WC and domain-specific cognitive functions measured by 12 neuropsychological tests were examined using multivariable linear regression models with covariates being age, sex, education, marital status, drinking status, smoking status, frequency of physical activity, total number of prescription medications, Japanese geriatric depression scale score, and medical histories (hypertension, cardiovascular diseases, diabetes mellitus, stroke and cancer). 122, 142 and 61 participants were in the age group of 65-74, 75–84 and 85+ years old, respectively and approximately half of them were female. The mean age (SD) [range] was 77.5 years (7.2) [66.0–98.0] and the mean WC (SD) [range] was 83.4 cm (9.9) [56.0–115.0] cm. WC was positively associated with the Wechsler Adult Intelligence Scale-Revised Digit Span Forward score (Attention/Working memory) among participants aged 65–74 years (p=0.002), but not in other age groups. Stratified by sex, WC was positively associated with the Digit Span Forward scores among 65-74-year-old women (p=0.005) while WC was negatively associated with the score among 75-84-year-old men (p=0.002). Some benefits of larger WC to Attention/Working memory were observed among non-demented young-old Japanese people, especially among younger older women, but not among men. This gender difference could be due to biological mechanisms including a critical role of the adipocyte-derived hormone on cognition among younger-older women. The results could aid in developing strategies to maintain cognitive health tailored for specific sex and age groups." @default.
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- W2980618300 date "2019-07-01" @default.
- W2980618300 modified "2023-10-14" @default.
- W2980618300 title "P4-426: WAIST CIRCUMFERENCE AND DOMAIN-SPECIFIC COGNITIVE FUNCTION AMONG THE NON-DEMENTED JAPANESE ELDERLY: RESULTS FROM THE TAKASHIMA STUDY" @default.
- W2980618300 doi "https://doi.org/10.1016/j.jalz.2019.06.4098" @default.
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