Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980625907> ?p ?o ?g. }
- W2980625907 endingPage "151853" @default.
- W2980625907 startingPage "151853" @default.
- W2980625907 abstract "Glioma is the most common primary brain cancer, and half of patients present a diagnosis of glioblastoma (GBM), its most aggressive and lethal form. Conventional therapies, including surgery, radiotherapy, and chemotherapy, have not resulted in major ameliorations in GBM survival outcome, which remains extremely poor. Recent immunotherapy improvements for other tumors, coupled with growing knowledge of the complex interactions between malignant glioma cells and the immune system, led to an exponential increase in glioma immunotherapy research. However, immunotherapeutic strategies in GBM have not yet reached their full potential, mainly due to the limited understanding of the strong immunosuppressive microenvironment (TME) characterizing this tumor. Glioma-associated macrophages and microglia (GAMs) are key drivers of the local immunosuppression promoting tumor progression and its resistance to immunomodulating therapeutic strategies. Together with other myeloid cells, such as dendritic cells and neutrophils, GAMs actively shape glioma TME, modulate anti-tumoral immune response and support angiogenesis, tumor cell invasion and proliferation. In this review, we discuss the role of myeloid cells in the complex TME of glioma and the available clinical data on therapeutic strategies focusing on approaches that affect myeloid cells activity in GBM." @default.
- W2980625907 created "2019-10-25" @default.
- W2980625907 creator A5002018880 @default.
- W2980625907 creator A5014309794 @default.
- W2980625907 creator A5018870571 @default.
- W2980625907 creator A5021041745 @default.
- W2980625907 creator A5021465650 @default.
- W2980625907 creator A5021472413 @default.
- W2980625907 creator A5045158774 @default.
- W2980625907 creator A5050115769 @default.
- W2980625907 creator A5065174717 @default.
- W2980625907 creator A5070833456 @default.
- W2980625907 creator A5078381394 @default.
- W2980625907 creator A5082718236 @default.
- W2980625907 creator A5087201805 @default.
- W2980625907 date "2020-01-01" @default.
- W2980625907 modified "2023-10-15" @default.
- W2980625907 title "Role of myeloid cells in the immunosuppressive microenvironment in gliomas" @default.
- W2980625907 cites W1521384669 @default.
- W2980625907 cites W1588685142 @default.
- W2980625907 cites W1610936510 @default.
- W2980625907 cites W1757492577 @default.
- W2980625907 cites W1787923008 @default.
- W2980625907 cites W1850228883 @default.
- W2980625907 cites W1934903822 @default.
- W2980625907 cites W1952035774 @default.
- W2980625907 cites W1959427476 @default.
- W2980625907 cites W1970667811 @default.
- W2980625907 cites W1971595657 @default.
- W2980625907 cites W1972073193 @default.
- W2980625907 cites W1972724819 @default.
- W2980625907 cites W1974713508 @default.
- W2980625907 cites W1974847865 @default.
- W2980625907 cites W1975970616 @default.
- W2980625907 cites W1977676577 @default.
- W2980625907 cites W1978826381 @default.
- W2980625907 cites W1978834636 @default.
- W2980625907 cites W1981256215 @default.
- W2980625907 cites W1982488143 @default.
- W2980625907 cites W1984757323 @default.
- W2980625907 cites W1984775626 @default.
- W2980625907 cites W1985323012 @default.
- W2980625907 cites W1987021433 @default.
- W2980625907 cites W1989318291 @default.
- W2980625907 cites W1991873176 @default.
- W2980625907 cites W1994901446 @default.
- W2980625907 cites W1999755104 @default.
- W2980625907 cites W1999879982 @default.
- W2980625907 cites W2001717792 @default.
- W2980625907 cites W2002157461 @default.
- W2980625907 cites W2007316487 @default.
- W2980625907 cites W2008764774 @default.
- W2980625907 cites W2013895733 @default.
- W2980625907 cites W2020604769 @default.
- W2980625907 cites W2024672608 @default.
- W2980625907 cites W2027949469 @default.
- W2980625907 cites W2033130827 @default.
- W2980625907 cites W2035437489 @default.
- W2980625907 cites W2040385253 @default.
- W2980625907 cites W2041442332 @default.
- W2980625907 cites W2044685551 @default.
- W2980625907 cites W2048898424 @default.
- W2980625907 cites W2050007032 @default.
- W2980625907 cites W2051003757 @default.
- W2980625907 cites W2051910121 @default.
- W2980625907 cites W2053357559 @default.
- W2980625907 cites W2053393698 @default.
- W2980625907 cites W2057525070 @default.
- W2980625907 cites W2058669152 @default.
- W2980625907 cites W2060279158 @default.
- W2980625907 cites W2060895562 @default.
- W2980625907 cites W2066684749 @default.
- W2980625907 cites W2068335734 @default.
- W2980625907 cites W2073586533 @default.
- W2980625907 cites W2074274791 @default.
- W2980625907 cites W2076350894 @default.
- W2980625907 cites W2080631077 @default.
- W2980625907 cites W2093005409 @default.
- W2980625907 cites W2095940261 @default.
- W2980625907 cites W2097049582 @default.
- W2980625907 cites W2097995306 @default.
- W2980625907 cites W2100816580 @default.
- W2980625907 cites W2102489984 @default.
- W2980625907 cites W2104347254 @default.
- W2980625907 cites W2105100844 @default.
- W2980625907 cites W2108435419 @default.
- W2980625907 cites W2111354523 @default.
- W2980625907 cites W2112362882 @default.
- W2980625907 cites W2116583846 @default.
- W2980625907 cites W2125493895 @default.
- W2980625907 cites W2125521995 @default.
- W2980625907 cites W2125884672 @default.
- W2980625907 cites W2126811287 @default.
- W2980625907 cites W2126817554 @default.
- W2980625907 cites W2127716652 @default.
- W2980625907 cites W2127745150 @default.
- W2980625907 cites W2132174136 @default.
- W2980625907 cites W2142242761 @default.