Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980633602> ?p ?o ?g. }
- W2980633602 endingPage "105048" @default.
- W2980633602 startingPage "105048" @default.
- W2980633602 abstract "In natural environments, mammals can efficiently select actions based on noisy sensory signals and quickly adapt to unexpected outcomes to better exploit opportunities that arise in the future. Such feedback-based changes in behavior rely, in part, on long term plasticity within cortico-basal-ganglia-thalamic networks, driven by dopaminergic modulation of cortical inputs to the direct and indirect pathway neurons of the striatum. While the firing rates of striatal neurons have been shown to adapt across a range of feedback conditions, it remains difficult to directly assess the corticostriatal synaptic weight changes that contribute to these adaptive firing rates. In this work, we simulate the evolution of corticostriatal synaptic weights based on a spike timing-dependent plasticity rule driven by dopamine signaling that is induced by outcomes of actions in the context of a two-alternative forced choice task. Our results establish 1) that this plasticity model can successfully learn to select the most rewarding actions available, 2) that in the effective regime plasticity predominantly impacts direct pathway weights, evolving to drive action selection toward a more-rewarded action, and 3) that there can be coactivation of opposing populations within selected action channels, as observed experimentally. The model performance also agrees with the results of behavioral experiments carried out previously in human subjects using probabilistic reward paradigms." @default.
- W2980633602 created "2019-10-25" @default.
- W2980633602 creator A5003867733 @default.
- W2980633602 creator A5007331697 @default.
- W2980633602 creator A5035483798 @default.
- W2980633602 creator A5064289022 @default.
- W2980633602 date "2020-03-01" @default.
- W2980633602 modified "2023-10-12" @default.
- W2980633602 title "Corticostriatal synaptic weight evolution in a two-alternative forced choice task: a computational study" @default.
- W2980633602 cites W1524454091 @default.
- W2980633602 cites W1647678806 @default.
- W2980633602 cites W1807195566 @default.
- W2980633602 cites W1969089145 @default.
- W2980633602 cites W1969591714 @default.
- W2980633602 cites W1971976749 @default.
- W2980633602 cites W1975221291 @default.
- W2980633602 cites W1976710123 @default.
- W2980633602 cites W1979215131 @default.
- W2980633602 cites W1983818070 @default.
- W2980633602 cites W2005269174 @default.
- W2980633602 cites W2014610415 @default.
- W2980633602 cites W2019982479 @default.
- W2980633602 cites W2020925019 @default.
- W2980633602 cites W2022561563 @default.
- W2980633602 cites W2024365408 @default.
- W2980633602 cites W2039014242 @default.
- W2980633602 cites W2040418090 @default.
- W2980633602 cites W2055946027 @default.
- W2980633602 cites W2057029832 @default.
- W2980633602 cites W2058077554 @default.
- W2980633602 cites W2059863959 @default.
- W2980633602 cites W2062550654 @default.
- W2980633602 cites W2078633164 @default.
- W2980633602 cites W2084682097 @default.
- W2980633602 cites W2109152498 @default.
- W2980633602 cites W2129962758 @default.
- W2980633602 cites W2141166794 @default.
- W2980633602 cites W2149661045 @default.
- W2980633602 cites W2152681028 @default.
- W2980633602 cites W2167987951 @default.
- W2980633602 cites W2172799329 @default.
- W2980633602 cites W2223202113 @default.
- W2980633602 cites W2262104398 @default.
- W2980633602 cites W2263610200 @default.
- W2980633602 cites W2324481651 @default.
- W2980633602 cites W2403201881 @default.
- W2980633602 cites W2495730383 @default.
- W2980633602 cites W2507447634 @default.
- W2980633602 cites W2747405782 @default.
- W2980633602 cites W2749662979 @default.
- W2980633602 cites W2785323625 @default.
- W2980633602 cites W2790788952 @default.
- W2980633602 cites W2794747207 @default.
- W2980633602 cites W2799652277 @default.
- W2980633602 cites W2801746582 @default.
- W2980633602 cites W2888570661 @default.
- W2980633602 cites W2895540533 @default.
- W2980633602 cites W2952483740 @default.
- W2980633602 cites W2952557035 @default.
- W2980633602 cites W2953354537 @default.
- W2980633602 cites W4242770316 @default.
- W2980633602 doi "https://doi.org/10.1016/j.cnsns.2019.105048" @default.
- W2980633602 hasPublicationYear "2020" @default.
- W2980633602 type Work @default.
- W2980633602 sameAs 2980633602 @default.
- W2980633602 citedByCount "9" @default.
- W2980633602 countsByYear W29806336022020 @default.
- W2980633602 countsByYear W29806336022021 @default.
- W2980633602 countsByYear W29806336022022 @default.
- W2980633602 countsByYear W29806336022023 @default.
- W2980633602 crossrefType "journal-article" @default.
- W2980633602 hasAuthorship W2980633602A5003867733 @default.
- W2980633602 hasAuthorship W2980633602A5007331697 @default.
- W2980633602 hasAuthorship W2980633602A5035483798 @default.
- W2980633602 hasAuthorship W2980633602A5064289022 @default.
- W2980633602 hasConcept C121332964 @default.
- W2980633602 hasConcept C148132819 @default.
- W2980633602 hasConcept C151730666 @default.
- W2980633602 hasConcept C154945302 @default.
- W2980633602 hasConcept C15744967 @default.
- W2980633602 hasConcept C162536842 @default.
- W2980633602 hasConcept C166109690 @default.
- W2980633602 hasConcept C169760540 @default.
- W2980633602 hasConcept C170493617 @default.
- W2980633602 hasConcept C26760741 @default.
- W2980633602 hasConcept C2778187257 @default.
- W2980633602 hasConcept C2779343474 @default.
- W2980633602 hasConcept C2780062018 @default.
- W2980633602 hasConcept C2780791683 @default.
- W2980633602 hasConcept C41008148 @default.
- W2980633602 hasConcept C49937458 @default.
- W2980633602 hasConcept C50644808 @default.
- W2980633602 hasConcept C513476851 @default.
- W2980633602 hasConcept C529278444 @default.
- W2980633602 hasConcept C55493867 @default.
- W2980633602 hasConcept C62520636 @default.
- W2980633602 hasConcept C66949984 @default.
- W2980633602 hasConcept C86803240 @default.