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• W2980633951 abstract "One of the most powerful molecular motors discovered, to date, belongs to a phage, a type of virus that infects bacteria (1). The motor serves to package stiff, double-stranded DNA (dsDNA) into a preassembled, proteinaceous polyhedral container called the procapsid. The DNA is about 50 times longer than the size of the capsid and gets packaged and compressed by the motor at near-crystalline densities. The capsid holds up its end of the bargain, withstanding positive pressure differentials of up to 40 atm (2). The level of current understanding of this fascinating biological process was made possible, in great measure, by the development of in singulo approaches to packaging dynamics, adapted to phages. However, what works for one virus may hardly apply to another. Thus, in a great number of single-stranded RNA (ssRNA) viruses—the largest virus group on Earth—nucleic acid packaging occurs concurrently with, and indeed is part of, spontaneous assembly. No ATP-powered motor is involved here. Instead of great positive pressures, the final pressure exerted by the RNA, at equilibrium, is modest and negative (3). Disentangling the interplay between the 2 types of concurrent driving interactions—those among coat proteins and those between coat proteins and RNA—is far from trivial. Adding to the challenge, intermediates have a fleeting existence (milliseconds), while the sizes of ssRNA viruses that can assemble in vitro are small (tens of nanometers). This is why, up to now, the principal features of ssRNA virus assembly have been mainly supplied by theoretical models, structural arguments from static data, and ensemble-averaged dynamic experiments. In singulo methods that would offer the same level of real-time dynamics detail and direct insight as those applied to dsDNA phages 2 decades ago have been scarce. In PNAS, Garmann et al. (4) provide a compelling demonstration of the potential held by a wide-field optical … [↵][1]1Email: dragnea{at}indiana.edu. [1]: #xref-corresp-1-1" @default.
• W2980633951 created "2019-10-25" @default.
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• W2980633951 date "2019-10-17" @default.
• W2980633951 modified "2023-10-17" @default.
• W2980633951 title "Watching a virus grow" @default.
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• W2980633951 doi "https://doi.org/10.1073/pnas.1915986116" @default.
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