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• W2980667739 endingPage "e1008263" @default.
• W2980667739 startingPage "e1008263" @default.
• W2980667739 abstract "In Bacillus subtilis, the extracytoplasmic function σ factor σM regulates cell wall synthesis and is critical for intrinsic resistance to cell wall targeting antibiotics. The anti-σ factors YhdL and YhdK form a complex that restricts the basal activity of σM, and the absence of YhdL leads to runaway expression of the σM regulon and cell death. Here, we report that this lethality can be suppressed by gain-of-function mutations in yidC1 (spoIIIJ), which encodes the major YidC membrane protein insertase in B. subtilis. B. subtilis PY79 YidC1 (SpoIIIJ) contains a single amino acid substitution in a functionally important hydrophilic groove (Q140K), and this allele suppresses the lethality of high σM. Analysis of a library of YidC1 variants reveals that increased charge (+2 or +3) in the hydrophilic groove can compensate for high expression of the σM regulon. Derepression of the σM regulon induces secretion stress, oxidative stress and DNA damage responses, all of which can be alleviated by the YidC1Q140K substitution. We further show that the fitness defect caused by high σM activity is exacerbated in the absence of the SecDF protein translocase or σM-dependent induction of the Spx oxidative stress regulon. Conversely, cell growth is improved by mutation of specific σM-dependent promoters controlling operons encoding integral membrane proteins. Collectively, these results reveal how the σM regulon has evolved to up-regulate membrane-localized complexes involved in cell wall synthesis, and to simultaneously counter the resulting stresses imposed by regulon induction." @default.
• W2980667739 created "2019-10-25" @default.
• W2980667739 creator A5029976904 @default.
• W2980667739 creator A5063317141 @default.
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• W2980667739 date "2019-10-18" @default.
• W2980667739 modified "2023-10-11" @default.
• W2980667739 title "Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction" @default.
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• W2980667739 doi "https://doi.org/10.1371/journal.pgen.1008263" @default.
• W2980667739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6827917" @default.
• W2980667739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31626625" @default.
• W2980667739 hasPublicationYear "2019" @default.
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