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• W2980672318 abstract "Neonatal animals are extremely tolerant of hypothermia. However, cooling will ultimately lead to ventilatory arrest, or cessation of respiratory movements. Upon rewarming, ventilation can recover spontaneously (autoresuscitation). This study examined the effect of age (P0-P5) and the pons on respiratory-related output during hypothermic ventilatory arrest and recovery using a brainstem-spinal cord preparation of neonatal rats. As temperature fell, burst frequency slowed, burst duration increased, burst shape became fragmented and eventually respiratory arrest occurred in all preparations. Removing the pons had little effect on younger preparations (P0-P2). Older preparations (P4-P5) with the pons removed continued to burst at cooler temperatures compared to pons-intact preparations and burst durations were significantly longer. Episodic breathing patterns were observed in all preparations (all ages, pons on or off) at lower temperatures. At 27 °C, however, episodic breathing was only observed in younger preparations with the pons on. These data suggest that developmental changes occurring at the level of the pons underlie the loss of hypothermic tolerance and episodic breathing." @default.
• W2980672318 created "2019-10-25" @default.
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• W2980672318 date "2020-02-01" @default.
• W2980672318 modified "2023-09-24" @default.
• W2980672318 title "Effect of temperature, age and the pons on respiratory rhythm in the rat brainstem-spinal cord" @default.
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• W2980672318 doi "https://doi.org/10.1016/j.resp.2019.103333" @default.
• W2980672318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31634578" @default.
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