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- W2980676854 endingPage "118" @default.
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- W2980676854 abstract "Unpredicted human safety events in clinical trials for new drugs are costly in terms of human health and money. The drug discovery industry attempts to minimize those events with diligent preclinical safety testing. Current standard practices are good at preventing toxic compounds from being tested in the clinic; however, false negative preclinical toxicity results are still a reality. Continual improvement must be pursued in the preclinical realm. Higher-quality therapies can be brought forward with more information about potential toxicities and associated mechanisms. The zebrafish model is a bridge between in vitro assays and mammalian in vivo studies. This model is powerful in its breadth of application and tractability for research. In the past two decades, our understanding of disease biology and drug toxicity has grown significantly owing to thousands of studies on this tiny vertebrate. This Review summarizes challenges and strengths of the model, discusses the 3Rs value that it can deliver, highlights translatable and untranslatable biology, and brings together reports from recent studies with zebrafish focusing on new drug discovery toxicology." @default.
- W2980676854 created "2019-10-25" @default.
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- W2980676854 date "2019-10-18" @default.
- W2980676854 modified "2023-10-14" @default.
- W2980676854 title "Use of Zebrafish in Drug Discovery Toxicology" @default.
- W2980676854 cites W1121521847 @default.
- W2980676854 cites W1183202696 @default.
- W2980676854 cites W120232010 @default.
- W2980676854 cites W1558565840 @default.
- W2980676854 cites W1575075264 @default.
- W2980676854 cites W1615535881 @default.
- W2980676854 cites W1663154925 @default.
- W2980676854 cites W1779952546 @default.
- W2980676854 cites W1792368315 @default.
- W2980676854 cites W1803353123 @default.
- W2980676854 cites W1814951489 @default.
- W2980676854 cites W1912701812 @default.
- W2980676854 cites W1913169768 @default.
- W2980676854 cites W1918696209 @default.
- W2980676854 cites W1965164195 @default.
- W2980676854 cites W1965940508 @default.
- W2980676854 cites W1967105697 @default.
- W2980676854 cites W1967966713 @default.
- W2980676854 cites W1968532316 @default.
- W2980676854 cites W1968644495 @default.
- W2980676854 cites W1969128125 @default.
- W2980676854 cites W1969712562 @default.
- W2980676854 cites W1970255604 @default.
- W2980676854 cites W1971566808 @default.
- W2980676854 cites W1972238619 @default.
- W2980676854 cites W1972648073 @default.
- W2980676854 cites W1973461367 @default.
- W2980676854 cites W1974820129 @default.
- W2980676854 cites W1975362267 @default.
- W2980676854 cites W1975476831 @default.
- W2980676854 cites W1978053825 @default.
- W2980676854 cites W1978486653 @default.
- W2980676854 cites W1978880915 @default.
- W2980676854 cites W1979720326 @default.
- W2980676854 cites W1980043169 @default.
- W2980676854 cites W1981239255 @default.
- W2980676854 cites W1982617925 @default.
- W2980676854 cites W1984015906 @default.
- W2980676854 cites W1984056122 @default.
- W2980676854 cites W1985022434 @default.
- W2980676854 cites W1986345391 @default.
- W2980676854 cites W1987969211 @default.
- W2980676854 cites W1992663358 @default.
- W2980676854 cites W1993989119 @default.
- W2980676854 cites W1994083602 @default.
- W2980676854 cites W1995676967 @default.
- W2980676854 cites W1996214950 @default.
- W2980676854 cites W1997362383 @default.
- W2980676854 cites W2000275279 @default.
- W2980676854 cites W2000871541 @default.
- W2980676854 cites W2000899261 @default.
- W2980676854 cites W2003896813 @default.
- W2980676854 cites W2003991209 @default.
- W2980676854 cites W2004044589 @default.
- W2980676854 cites W2004261380 @default.
- W2980676854 cites W2005998762 @default.
- W2980676854 cites W2006424018 @default.
- W2980676854 cites W2007686965 @default.
- W2980676854 cites W2008724643 @default.
- W2980676854 cites W2009766076 @default.
- W2980676854 cites W2011403845 @default.
- W2980676854 cites W2011618088 @default.
- W2980676854 cites W2012836529 @default.
- W2980676854 cites W2013210063 @default.
- W2980676854 cites W2015157164 @default.
- W2980676854 cites W2015796769 @default.
- W2980676854 cites W2016741820 @default.
- W2980676854 cites W20181848 @default.
- W2980676854 cites W2018570986 @default.
- W2980676854 cites W2022182678 @default.
- W2980676854 cites W2022295910 @default.
- W2980676854 cites W2024634562 @default.
- W2980676854 cites W2025894647 @default.
- W2980676854 cites W2028278455 @default.
- W2980676854 cites W2028426134 @default.
- W2980676854 cites W2028465517 @default.
- W2980676854 cites W2029032529 @default.
- W2980676854 cites W2030058339 @default.
- W2980676854 cites W2031493473 @default.
- W2980676854 cites W2031539931 @default.
- W2980676854 cites W2032205612 @default.
- W2980676854 cites W2037977783 @default.
- W2980676854 cites W2038711150 @default.