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- W2980685447 abstract "Systemic inflammatory markers, such as C-reactive protein (CRP) have been associated with risk and progression of cognitive impairment. However, most of the work in this area has examined cross-sectional associations or has used single assessments of inflammatory markers as predictors of cognitive change. Repeated assessments of CRP are needed to explore potentially reciprocal associations between inflammation and cognition as these variables fluctuate over time. Data were from 6073 US adults over age 50 (Mage = 66.88 years, 60.05% female) from the Health and Retirement Study who provided blood specimens beginning in 2006. Bivariate growth modeling, an extension of longitudinal structural equation modeling, was used to simultaneously estimate trajectories of CRP and cognition over an eight-year follow-up. Two separate models were estimated. The first model included all available participants and estimated changes in CRP and cognition as a function of time in years since the initial assessment. The second model examined a subset of 445 participants who developed dementia after the baseline assessment with time structured as time to diagnosis. Age, sex, education, chronic conditions, and dementia status were included as covariates on the intercept and slope parameters in both models. In the overall sample, cognition and CRP declined with advancing age. Male participants and those with higher education had lower initial levels of CRP, but greater increases over time. A significant negative correlation (r = −.09, p = .017) was observed between intercepts for CRP and cognitive function, but not between slopes (r = −.07, p = .612). Cognitive intercepts were marginally associated with CRP slopes (r = .11, p = .085), indicating that higher cognitive functioning at baseline predicted less decline or more stable CRP levels across the study. In the dementia subsample, no significant associations were observed in levels or rates of change in CRP and cognition. CRP may predict level of cognitive ability, though these variables do not appear to change concurrently over time. Cognition and CRP were not associated in the subsample with incident dementia, suggesting that CRP may be a better predictor of normative cognitive aging." @default.
- W2980685447 created "2019-10-25" @default.
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- W2980685447 date "2019-07-01" @default.
- W2980685447 modified "2023-09-28" @default.
- W2980685447 title "P4-534: COUPLED BIVARIATE CHANGES IN C-REACTIVE PROTEIN AND COGNITION IN LATE LIFE" @default.
- W2980685447 doi "https://doi.org/10.1016/j.jalz.2019.08.081" @default.
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