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• W2980711285 abstract "Abstract Objective Global factors have been identified in measures of cognitive performance (i.e., Spearman’s g ) and psychopathology (i.e., “General Psychopathology”, “ p ”). Dementia is also strongly determined by the latent phenotype “δ”, derived from g . We wondered if the Behavior and Psychological Symptoms of Dementia (BPSD) might arise from an association between δ and p . Methods δ and p were constructed by confirmatory factor analyses in data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). δ and orthogonal factors representing “domain-specific” variance in memory (MEM) and executive function (EF) were regressed onto p and orthogonal factors representing “domain-specific” variance in positive (+) and negative (-) symptoms rated by the Neuropsychiatric Inventory Nursing Home Questionnaire (NPI-Q) by multiple regression in a structural equation model (SAM) framework. Results Model fit was excellent (CFI = 0.98, RMSEA = 0.03). δ was strongly associated with p , (+) and (-) and strongly associated with p (r = −0.57, p<0.001). All three associations were inverse (adverse). Independently of δ, MEM was uniquely associated with (+), while ECF was associated with (-). Both associations were moderately strong. ECF was also weakly associated with p . Conclusions Dementia severity (δ) derived from general intelligence ( g ) is specifically associated with general psychopathology ( p ). This is p ’s first demonstration in an elderly sample and the first to distinguish the global behavioral and psychological symptoms specific to dementia (BPSSD) from behavioral disturbances arising by way of non-dementing, albeit likely disease-specific, processes affecting domain-specific cognitive and behavioral constructs. Our findings call into question the utility of proposed regional interventions in BPSSD, and point to the need to explore global interventions against dementia-specific behavioral features." @default.
• W2980711285 created "2019-10-25" @default.
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• W2980711285 date "2019-10-21" @default.
• W2980711285 modified "2023-10-18" @default.
• W2980711285 title "Dementia is Associated with a Syndrome of Global Neuropsychiatric Disturbance" @default.
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• W2980711285 doi "https://doi.org/10.1101/813485" @default.
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