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• W2980722212 abstract "Tauopathies are a heterogeneous group of disease characterized by abnormal tau aggregates in neurons and glial cells. Neuropathological diagnosis is based on cellular involvement and topography brain distribution. During the last years, diseases associated to tau pathology have been better characterized. However, some of these remain unclassified, according proposed criteria. Here we describe cases showing Alzheimer's-type pathology and features of other tauopathies which did not fulfil criteria for any specific neurodegenerative disease. We described demographic, clinical and neuropathological data of nine cases from the Biobank for Aging Studies of the University of São Paulo. Staging and diagnosis of brain pathologies were performed based on internationally accepted criteria. Moreover, tau-immunostained sections (AT8) of frontal cortex, temporal cortex, parietal cortex, basal ganglia, hippocampus, amygdala, midbrain and medulla were analyzed. Presence of tau-positive aggregates in astrocytes and oligodendrocytes were evaluated considering morphology, localization and severity. Demographic and clinical data were collected through interviews with a next-of-kin. Cognitive and neuropsychiatric symptoms (NPS) were evaluated, according the Clinical dementia rating scale, and neuropsychiatric inventory respectively. The mean age was 71±11y, 44% (4) were Caucasian. Cognitive impairment (CI) was reported only in three individuals. In contrast, 67% had some degree of NPS. In common these cases present moderate neurofibrillary pathology (Braak staging III-IV) associated to tau aggregates in astrocytes, mainly as thorn-shaped, granular and fuzzy astrocytes morphologies (ARTAG). Few tau-positive astrocytes, resembling those of primary tauopathies (Non-ARTAG) were identified. Additionally, neuropathological alterations of other tauopathies as tau inclusions in oligodendrocytes and grains were frequently found, mainly sparse. Tau astroglial pathology was most prominent in amygdala, except in two cases showing severe involvement of the dentate gyrus of hippocampus. Lewy-type pathology and neuritic plaques were found only in one case (Braak PD 3; CERAD A). APOE genotyping was available for four participants. Interestingly, the individual with earlier onset of CI with subcortical and cortical tau pathology had APOEε4. Tau astroglial pathology was frequently observed, mostly associated to alterations of other tauopathies. Noteworthy, high prevalence of NPS was noted. Admixed population-based studies can contribute to the better understanding of these tauopathies, their prevalence and impact on neurodegeneration." @default.
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• W2980722212 date "2019-07-01" @default.
• W2980722212 modified "2023-10-17" @default.
• W2980722212 title "P4-342: CLINICAL AND NEUROPATHOLOGICAL FINDINGS OF UNCLASSIFIED TAUOPATHY CASES FROM A LARGE POPULATION-BASED STUDY" @default.
• W2980722212 doi "https://doi.org/10.1016/j.jalz.2019.06.4012" @default.
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