Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980757673> ?p ?o ?g. }
- W2980757673 endingPage "100670" @default.
- W2980757673 startingPage "100670" @default.
- W2980757673 abstract "Triple-negative breast cancer (TNBC) is very aggressive with high metastatic and mortality rates and unfortunately, except for chemotherapy, there are few therapeutic options. The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) regulates numerous processes important for cancer progression, metastasis, and neuropathic pain. The pro-drug FTY720 (fingolimod, Gilenya) used to treat multiple sclerosis is phosphorylated in the body to a S1P mimic that binds to S1PRs, except S1PR2, and also acts as a functional antagonist of S1PR1. This review highlights current findings showing that FTY720 has multiple anti-cancer activities and simultaneously prevents formation and actions of S1P. Moreover, in mouse breast cancer models, treatment with FTY720 reduces tumor growth, metastasis, and enhances sensitivity of advanced and hormonal refractory breast cancer and TNBC to conventional therapies. We discuss recent studies demonstrating that neuropathic pain induced by the chemotherapeutic bortezomib is also greatly reduced by administration of clinically relevant doses of FTY720, likely by targeting S1PR1 on astrocytes. FTY720 also shows promising anticancer potential in pre-clinical studies and is FDA approved, thus we suggest in this review that further studies are needed to pave the way for fast-tracking approval of FTY720/fingolimod for enhancing chemotherapy effectiveness and reduction of painful neuropathies." @default.
- W2980757673 created "2019-10-25" @default.
- W2980757673 creator A5014072958 @default.
- W2980757673 creator A5075604562 @default.
- W2980757673 date "2020-01-01" @default.
- W2980757673 modified "2023-10-12" @default.
- W2980757673 title "Sphingosine-1-phosphate signaling: A novel target for simultaneous adjuvant treatment of triple negative breast cancer and chemotherapy-induced neuropathic pain" @default.
- W2980757673 cites W1518204217 @default.
- W2980757673 cites W1561012079 @default.
- W2980757673 cites W1585521882 @default.
- W2980757673 cites W1781293224 @default.
- W2980757673 cites W1900480423 @default.
- W2980757673 cites W1966452335 @default.
- W2980757673 cites W1969996654 @default.
- W2980757673 cites W1977663897 @default.
- W2980757673 cites W1982334431 @default.
- W2980757673 cites W1983079076 @default.
- W2980757673 cites W1987474302 @default.
- W2980757673 cites W1993747196 @default.
- W2980757673 cites W1995982280 @default.
- W2980757673 cites W1996331246 @default.
- W2980757673 cites W1996605319 @default.
- W2980757673 cites W1998033088 @default.
- W2980757673 cites W2022585261 @default.
- W2980757673 cites W2031268426 @default.
- W2980757673 cites W2034607874 @default.
- W2980757673 cites W2036637024 @default.
- W2980757673 cites W2040595891 @default.
- W2980757673 cites W2054275187 @default.
- W2980757673 cites W2056697413 @default.
- W2980757673 cites W2062071281 @default.
- W2980757673 cites W2077885131 @default.
- W2980757673 cites W2078794107 @default.
- W2980757673 cites W2082579490 @default.
- W2980757673 cites W2083397512 @default.
- W2980757673 cites W2091423973 @default.
- W2980757673 cites W2097202436 @default.
- W2980757673 cites W2102478723 @default.
- W2980757673 cites W2113493868 @default.
- W2980757673 cites W2116287565 @default.
- W2980757673 cites W2120183929 @default.
- W2980757673 cites W2127461273 @default.
- W2980757673 cites W2143960928 @default.
- W2980757673 cites W2145876349 @default.
- W2980757673 cites W2149615364 @default.
- W2980757673 cites W2151217876 @default.
- W2980757673 cites W2151264766 @default.
- W2980757673 cites W2158353135 @default.
- W2980757673 cites W2176105721 @default.
- W2980757673 cites W2314946663 @default.
- W2980757673 cites W2320179271 @default.
- W2980757673 cites W2394518860 @default.
- W2980757673 cites W2527362193 @default.
- W2980757673 cites W2620945337 @default.
- W2980757673 cites W2729490109 @default.
- W2980757673 cites W2734714741 @default.
- W2980757673 cites W2745198661 @default.
- W2980757673 cites W2755379397 @default.
- W2980757673 cites W2756069931 @default.
- W2980757673 cites W2767144255 @default.
- W2980757673 cites W2769383666 @default.
- W2980757673 cites W2793775313 @default.
- W2980757673 cites W2794197589 @default.
- W2980757673 cites W2802277418 @default.
- W2980757673 cites W2893349290 @default.
- W2980757673 cites W2897226109 @default.
- W2980757673 cites W2898349133 @default.
- W2980757673 cites W2916155651 @default.
- W2980757673 cites W2943924499 @default.
- W2980757673 cites W2955028868 @default.
- W2980757673 doi "https://doi.org/10.1016/j.jbior.2019.100670" @default.
- W2980757673 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31708456" @default.
- W2980757673 hasPublicationYear "2020" @default.
- W2980757673 type Work @default.
- W2980757673 sameAs 2980757673 @default.
- W2980757673 citedByCount "25" @default.
- W2980757673 countsByYear W29807576732020 @default.
- W2980757673 countsByYear W29807576732021 @default.
- W2980757673 countsByYear W29807576732022 @default.
- W2980757673 countsByYear W29807576732023 @default.
- W2980757673 crossrefType "journal-article" @default.
- W2980757673 hasAuthorship W2980757673A5014072958 @default.
- W2980757673 hasAuthorship W2980757673A5075604562 @default.
- W2980757673 hasBestOaLocation W29807576731 @default.
- W2980757673 hasConcept C121608353 @default.
- W2980757673 hasConcept C126322002 @default.
- W2980757673 hasConcept C143998085 @default.
- W2980757673 hasConcept C170493617 @default.
- W2980757673 hasConcept C2776596873 @default.
- W2980757673 hasConcept C2776694085 @default.
- W2980757673 hasConcept C2777107010 @default.
- W2980757673 hasConcept C2777863537 @default.
- W2980757673 hasConcept C2778703144 @default.
- W2980757673 hasConcept C2780110267 @default.
- W2980757673 hasConcept C502942594 @default.
- W2980757673 hasConcept C530470458 @default.
- W2980757673 hasConcept C71924100 @default.
- W2980757673 hasConcept C98274493 @default.