Matches in SemOpenAlex for { <https://semopenalex.org/work/W2980771157> ?p ?o ?g. }
- W2980771157 endingPage "965" @default.
- W2980771157 startingPage "950" @default.
- W2980771157 abstract "S100 calcium-binding protein A9 (S100a9), a proinflammatory protein, has been shown to be involved in the development of neuroinflammatory disorders and neurodegenerative diseases. Upregulation of S100a9 in the brain during acute brain injury has been proposed to be associated with acute neuroinflammation. However, it remains unclear whether eliminating S100a9 expression will show beneficial outcomes after traumatic brain injury (TBI). Using S100a9 knockout mice, this study has demonstrated that S100a9 deletion ameliorates post-TBI anxiety, improves TBI-impaired motor and cognitive function, reduces lesion size, prevents perilesional neuron loss and neurodegeneration, diminishes neuroinflammation and TBI-induced neurogenesis, and enhances perilesional expression of neuroplasticity protein. These findings suggest that S100a9 plays a detrimental role in TBI. Genetic deletion of S100a9 enhances neuroprotection and improves functional outcome after TBI. This study sheds light on the pathological involvement of S100a9 in TBI, which would provide a new therapeutic target to minimize TBI-induced brain damage." @default.
- W2980771157 created "2019-10-25" @default.
- W2980771157 creator A5014274424 @default.
- W2980771157 creator A5034379112 @default.
- W2980771157 creator A5049275369 @default.
- W2980771157 creator A5069758035 @default.
- W2980771157 creator A5075326500 @default.
- W2980771157 creator A5083139049 @default.
- W2980771157 date "2020-04-01" @default.
- W2980771157 modified "2023-09-27" @default.
- W2980771157 title "S100 Calcium-Binding Protein A9 Knockout Contributes to Neuroprotection and Functional Improvement after Traumatic Brain Injury" @default.
- W2980771157 cites W1663685470 @default.
- W2980771157 cites W1838129259 @default.
- W2980771157 cites W1878762030 @default.
- W2980771157 cites W1950981769 @default.
- W2980771157 cites W1967061503 @default.
- W2980771157 cites W1968594434 @default.
- W2980771157 cites W1975466068 @default.
- W2980771157 cites W1977818517 @default.
- W2980771157 cites W1978957620 @default.
- W2980771157 cites W1984305500 @default.
- W2980771157 cites W1990042222 @default.
- W2980771157 cites W1993437264 @default.
- W2980771157 cites W2001442825 @default.
- W2980771157 cites W2005859239 @default.
- W2980771157 cites W2010635769 @default.
- W2980771157 cites W2017656054 @default.
- W2980771157 cites W2017816448 @default.
- W2980771157 cites W2019140289 @default.
- W2980771157 cites W2021280339 @default.
- W2980771157 cites W2024930566 @default.
- W2980771157 cites W2028796446 @default.
- W2980771157 cites W2028938479 @default.
- W2980771157 cites W2035408187 @default.
- W2980771157 cites W2037200077 @default.
- W2980771157 cites W2043441080 @default.
- W2980771157 cites W2049776725 @default.
- W2980771157 cites W2050889407 @default.
- W2980771157 cites W2061820832 @default.
- W2980771157 cites W2066663538 @default.
- W2980771157 cites W2067003329 @default.
- W2980771157 cites W2067448822 @default.
- W2980771157 cites W2069338913 @default.
- W2980771157 cites W2075031095 @default.
- W2980771157 cites W2075089959 @default.
- W2980771157 cites W2076492394 @default.
- W2980771157 cites W2077100662 @default.
- W2980771157 cites W2087592242 @default.
- W2980771157 cites W2090950838 @default.
- W2980771157 cites W2096597907 @default.
- W2980771157 cites W2103491454 @default.
- W2980771157 cites W2104159920 @default.
- W2980771157 cites W2104489799 @default.
- W2980771157 cites W2107521515 @default.
- W2980771157 cites W2124118965 @default.
- W2980771157 cites W2136159763 @default.
- W2980771157 cites W2137368645 @default.
- W2980771157 cites W2142733734 @default.
- W2980771157 cites W2146373526 @default.
- W2980771157 cites W2147849931 @default.
- W2980771157 cites W2155556701 @default.
- W2980771157 cites W2159245482 @default.
- W2980771157 cites W2161475511 @default.
- W2980771157 cites W2205327799 @default.
- W2980771157 cites W2252799842 @default.
- W2980771157 cites W2297952971 @default.
- W2980771157 cites W2331252089 @default.
- W2980771157 cites W2343079527 @default.
- W2980771157 cites W2410124894 @default.
- W2980771157 cites W24158534 @default.
- W2980771157 cites W2545491991 @default.
- W2980771157 cites W2547325155 @default.
- W2980771157 cites W2581780754 @default.
- W2980771157 cites W2589536288 @default.
- W2980771157 cites W2595085771 @default.
- W2980771157 cites W2791831005 @default.
- W2980771157 cites W2805899912 @default.
- W2980771157 doi "https://doi.org/10.1089/neu.2018.6170" @default.
- W2980771157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31621496" @default.
- W2980771157 hasPublicationYear "2020" @default.
- W2980771157 type Work @default.
- W2980771157 sameAs 2980771157 @default.
- W2980771157 citedByCount "8" @default.
- W2980771157 countsByYear W29807711572021 @default.
- W2980771157 countsByYear W29807711572022 @default.
- W2980771157 countsByYear W29807711572023 @default.
- W2980771157 crossrefType "journal-article" @default.
- W2980771157 hasAuthorship W2980771157A5014274424 @default.
- W2980771157 hasAuthorship W2980771157A5034379112 @default.
- W2980771157 hasAuthorship W2980771157A5049275369 @default.
- W2980771157 hasAuthorship W2980771157A5069758035 @default.
- W2980771157 hasAuthorship W2980771157A5075326500 @default.
- W2980771157 hasAuthorship W2980771157A5083139049 @default.
- W2980771157 hasConcept C118552586 @default.
- W2980771157 hasConcept C126322002 @default.
- W2980771157 hasConcept C142724271 @default.
- W2980771157 hasConcept C15744967 @default.
- W2980771157 hasConcept C169760540 @default.