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- W2980771231 abstract "Up to 40% of new patients in memory clinics complain of worse cognitive performance but score within normal ranges in cognitive tests, hence presenting subjective cognitive decline (SCD). Although usually dismissed, they present an increased progression rate to mild cognitive impairment (MCI) and dementia of 6.67% and 2.33%, respectively. There is, therefore, an emergent need for newly designed programs to provide individual risk estimates and tailored risk-reduction action plans. With the aim of assessing the emotional impact and cost-benefit of these programs, we established the BarcelonaBeta Dementia Prevention Research Clinic (BBDPRC). A multimodal interventional, longitudinal, prospective study of 425 participants (60-80 years) with SCD or MCI has been set-up. General population participants concerned about their cognitive performance are pre-selected by an algorithm through web-based forms capturing information about their subjective cognitive performance. Those selected undergo baseline visit for (1) diagnosis (SCD/MCI), (2) collecting data feeding a dementia risk algorithm and (3) getting their personalised prevention action plan. At the subsequent visit, their risk estimates are disclosed and a personalised primary prevention advice given. Individuals with MCI are readily offered to enter studies and trials they may benefit from. The emotional impact of disclosure is measured at 1 and 6 weeks and 6 and 12 months post-disclosure. At 6-weeks, SCD participants are also offered to enter suitable prevention trials (Fig.1). Cost-benefit of this program will also be calculated using standard methods. BBDPRC was presented in a press conference and 715 persons registered in the study's webpage in 48 hours (∼1,600, 8 months later): 53.2% of them were classified as a priori eligible (Fig.2) and ∼100 have undergone baseline visit (screening failure rate<9%). Of them, 22.4% have been diagnosed as MCI, 49.3% as SCD+ (fulfilling >3 SCD+ features) and 28.3% as SCD. More than half (58.2%) of these participants comply with eligibility criteria with ongoing studies at BBRC (Fig.3)." @default.
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- W2980771231 date "2019-07-01" @default.
- W2980771231 modified "2023-10-06" @default.
- W2980771231 title "P1-535: THE BARCELONAβETA DEMENTIA PREVENTION RESEARCH CLINIC: STUDY DESIGN, RECRUITMENT PROFILES AND PARTICIPANTS INCLUSION IN PREVENTION STUDIES" @default.
- W2980771231 doi "https://doi.org/10.1016/j.jalz.2019.06.1140" @default.
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