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- W2980772687 abstract "With people reaching older ages worldwide, understanding the natural course of cognitive and motor function in individuals is of utmost importance. Extensive data exist on cognitive and motor function at different ages, yet the rate and sequence of decline of different neuropsychological and motor function tests across levels of education are less studied. Moreover, it remains inconclusive whether a deterioration in motor function parallels cognitive decline or whether decline in one precedes the other. We repeatedly assessed cognitive function based on the MMSE and five neuropsychological tests between 1990 and 2016 in 11,997 participants from the Rotterdam Study who were aged ≥45 years and free of dementia, stroke, and Parkinson's disease. From 1999 onwards, we additionally measured motor function with three different tests that measure different facets of motor function in 8,536 participants. Linear mixed models were used to assess education-specific trajectories of cognitive and motor function and to determine sequences of change of test scores. The median number of cognitive and motor assessments per participant was two (range 1–8 and 1-4), with a mean (SD) test interval of 4.3 years (1.9 years) and 5.5 years (1.4 years). Decline in cognitive function paralleled decline of motor function across all educational levels, characterized by accelerating decline after the age of 67.0 for most tests. However, test-specific decline was highly variable. For instance, first decline in test performance was observed at age 55 years, whereas others reached their first significant decline beyond the age of 80. A lower education was associated with lower baseline cognitive function, but did not affect the rate of cognitive decline. Educational level was not associated with baseline motor function and did not alter the rate of decline in motor function." @default.
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- W2980772687 date "2019-07-01" @default.
- W2980772687 modified "2023-10-02" @default.
- W2980772687 title "O3-06-02: COGNITIVE AND MOTOR FUNCTION IN AGING COMMUNITY-DWELLING INDIVIDUALS: THE ROTTERDAM STUDY" @default.
- W2980772687 doi "https://doi.org/10.1016/j.jalz.2019.06.4655" @default.
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